The functional PTPN22 C1858T polymorphism confers risk for rheumatoid arthritis in patients from Central Mexico
Rheumatoid arthritis (RA) is a complex genetic disease. Human leukocyte antigen (HLA) and non-HLA genes are reportedly associated with an increased risk of RA. The protein tyrosine phosphatase non-receptor 22 gene ( PTPN22 ), which encodes the lymphoid tyrosine phosphatase (LYP) protein, is one of t...
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Published in | Clinical rheumatology Vol. 35; no. 6; pp. 1457 - 1462 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
London
Springer London
01.06.2016
Springer Nature B.V |
Subjects | |
Online Access | Get full text |
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Summary: | Rheumatoid arthritis (RA) is a complex genetic disease. Human leukocyte antigen (HLA) and non-HLA genes are reportedly associated with an increased risk of RA. The protein tyrosine phosphatase non-receptor 22 gene (
PTPN22
), which encodes the lymphoid tyrosine phosphatase (LYP) protein, is one of the best examples of a non-HLA gene associated with a risk for RA in several populations. The functional
PTPN22
C1858T (R620W) non-synonymous polymorphism is widely associated with an increased risk for RA in Europeans and non-Europeans. The aim of this study was to determine if the
PTPN22
C1858T polymorphism confers susceptibility to RA in a sample of patients from Mexico. This study included 364 RA patients and 387 non-related controls from Central Mexico. Genotyping of the
PTPN22
C1858T (rs2476601) polymorphism was performed using allelic discrimination assays with TaqMan probes. The functional
PTPN22
C1858T polymorphism was associated with an increased risk for RA in our study population. The CC vs CT genotype in RA patients versus healthy controls had an odds ratio (OR) of 4.17 (95 % CI 1.79–9.74,
p
= 0.00036), while T allele had an OR of 4.06 (95 % CI 1.75–9.41,
p
= 0.00043).
PTPN22
is a genetic risk factor for developing RA in the Mexican population. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0770-3198 1434-9949 |
DOI: | 10.1007/s10067-016-3223-z |