A new infant hybrid respiratory simulator: preliminary evaluation based on clinical data
A new hybrid (numerical–physical) simulator of the respiratory system, designed to simulate spontaneous and artificial/assisted ventilation of preterm and full-term infants underwent preliminary evaluation. A numerical, seven-compartmental model of the respiratory system mechanics allows the operato...
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Published in | Medical & biological engineering & computing Vol. 55; no. 11; pp. 1937 - 1948 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Berlin/Heidelberg
Springer Berlin Heidelberg
01.11.2017
Springer Nature B.V |
Subjects | |
Online Access | Get full text |
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Summary: | A new hybrid (numerical–physical) simulator of the respiratory system, designed to simulate spontaneous and artificial/assisted ventilation of preterm and full-term infants underwent preliminary evaluation. A numerical, seven-compartmental model of the respiratory system mechanics allows the operator to simulate global and peripheral obstruction and restriction of the lungs. The physical part of the simulator is a piston-based construction of impedance transformer. LabVIEW real-time software coordinates the work of both parts of the simulator and its interaction with a ventilator. Using clinical data, five groups of “artificial infants” were examined: healthy full-term infants, very low-birth-weight preterm infants successfully (VLBW) and unsuccessfully extubated (VLBWun) and extremely low-birth-weight preterm infants without (ELBW) and with bronchopulmonary dysplasia (ELBW_BPD). Pressure-controlled ventilation was simulated to measure peak inspiratory pressure, mean airway pressure, total (patient + endotracheal tube) airway resistance (
R
), total dynamic compliance of the respiratory system (
C
), and total work of breathing by the ventilator (WOB). The differences between simulation and clinical parameters were not significant. High correlation coefficients between both types of data were obtained for
R
,
C
, and WOB (γ
R
= 0.99,
P
< 0.0005; γ
C
= 0.85,
P
< 0.005; γ
WOB
= 0.96,
P
< 0.05, respectively). Thus, the simulator accurately reproduces infant respiratory system mechanics. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0140-0118 1741-0444 |
DOI: | 10.1007/s11517-017-1635-9 |