Synthesis of 2-arylbenzimidazoles via microwave Suzuki–Miyaura reaction of unprotected 2-chlorobenzimidazoles

A series of 2-arylbenzimidazoles were synthesized via microwave-mediated Suzuki–Miyaura coupling of 2-chloro benzimidazoles and either arylboronic acids or aryltrifluoroborate salts. The most notable aspect of the present work is that there is no need for protection of the benzimidazoles. In additio...

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Bibliographic Details
Published inTetrahedron letters Vol. 49; no. 47; pp. 6667 - 6669
Main Authors Savall, Brad M., Fontimayor, Jill R.
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 17.11.2008
Elsevier
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
BENZIMIDAZOLES
CATALYST
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Summary:A series of 2-arylbenzimidazoles were synthesized via microwave-mediated Suzuki–Miyaura coupling of 2-chloro benzimidazoles and either arylboronic acids or aryltrifluoroborate salts. The most notable aspect of the present work is that there is no need for protection of the benzimidazoles. In addition, reaction conditions were optimized to reduce homo coupling of pyridylboronic acids.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2008.09.043