Carcinogenesis: the cancer cell–mast cell connection

• Published in: Inflammation research Vol. 68; no. 2; pp. 103 - 116
• Main Authors: Aller, Maria-Angeles, Arias, Ana, Arias, Jose-Ignacio, Arias, Jaime
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.02.2019; Springer Nature B.V
• Subjects: Allergology; Amnion; Biomedical and Life Sciences; Biomedicine; Cancer; Carcinogenesis; Carcinogens; Dermatology; Embryogenesis; Embryonic growth stage; Heterogeneity; Histamine; Immunology; Inflammation; Mast cells; Metastases; Neurology; Pharmacology/Toxicology; Phenotypes; Review; Rheumatology; Stem cells; Tumorigenesis; Tumors; Wound healing; Yolk; Yolk sac; Amniotic; Mast cell; Ischemia–reperfusion; Chronic inflammation; Vitelline; Cancer
• ISSN: 1023-3830; 1420-908X
• DOI: 10.1007/s00011-018-1201-4

Background In mammals, inflammation is required for wound repair and tumorigenesis. However, the events that lead to inflammation, particularly in non-healing wounds and cancer, are only partly understood. Findings Mast cells, due to their great plasticity, could orchestrate the inflammatory responses inducing the expression of extraembryonic programs of normal and pathological tissue formation. This heterogeneity of mast cells could allow a microenvironment to be recreated similar to the extraembryonic structures, i.e., amnion and yolk sac, which are needed for embryonic development. Mast cells could provide a framework for understanding the connection between inflammation and tumor growth, invasion and metastasis. In this way, the mast cells could express inflammatory phenotypes, which would enable the cancer stem cells to develop. Thus, the cancer cell uses mast cells to express the extraembryonic functions that are needed to allow the cancer stem cell to proliferate and invade. If so, then by using this appropriate inflammatory interstitial microenvironment, a cancer stem cell can reach maximum levels of growth and invasion inside the host. Conclusion Therefore, the comparison of tumors with wounds that do not heal would be supported since both pathological processes use extraembryonic mechanisms by mast cells. The adoption of these mechanisms warrants tumor survival in an embryonic-like state.