Genetic association analysis of Osteopontin and Matrix Gla Protein genes polymorphisms with primary knee osteoarthritis in Mexican population

• Published in: Clinical rheumatology Vol. 38; no. 1; pp. 223 - 228
• Main Authors: Borgonio-Cuadra, Verónica Marusa, González-Huerta, Norma Celia, Rojas-Toledo, Emma Xochitl, Morales-Hernández, Eugenio, Pérez-Hernández, Nonanzit, Rodríguez-Pérez, José Manuel, Tovilla-Zárate, Carlos Alfonso, González-Castro, Thelma Beatriz, Hernández-Díaz, Yazmín, López-Narváez, María Lilia, Miranda-Duarte, Antonio
• Format: Journal Article
• Language: English
• Published: London Springer London 01.01.2019; Springer Nature B.V
• Subjects: Aged; Arthritis; Association analysis; Bone growth; Brief Report; Calcium-Binding Proteins - genetics; Case-Control Studies; Extracellular Matrix Proteins - genetics; Female; Genetic analysis; Genetic Association Studies; Genetic diversity; Haplotypes; Humans; Knee; Logistic Models; Male; Matrix Gla Protein; Medicine; Medicine & Public Health; Mexico; Middle Aged; Mineralization; Osteoarthritis; Osteoarthritis, Knee - genetics; Osteogenesis; Osteopontin; Osteopontin - genetics; Polymorphism, Single Nucleotide; Population studies; Rheumatology; Mexico; Knee; Osteopontin; Genetics; Matrix Gla protein; Osteoarthritis; Polymorphism
• ISSN: 0770-3198; 1434-9949; 1434-9949
• DOI: 10.1007/s10067-018-4146-7

Primary osteoarthritis (OA) is a complex entity in which several loci related to different molecular pathways or classes of molecules are associated with its development as demonstrated through genetic association studies. Genes involved in bone formation and mineralization, such as osteopontin ( OPN ) and Matrix Gla protein ( MGP ), could also be related with OA. The aim of this study was to evaluate the association between the genetic variants of OPN and MGP with primary knee osteoarthritis in a Mexican population. A case-control study was conducted in 296 patients with primary knee osteoarthritis and in 354 control subjects. Study groups were assessed radiologically. The rs11730582 of OPN and rs1800802, rs1800801, and rs4236 of MGP were determined by TaqMan allele discrimination assays. The haplotypes of the polymorphisms of MGP were constructed. The association was tested through univariate and multivariate non-conditional logistic regression analyses. The polymorphisms of MGP complied with Hardy-Weinberg (HW) equilibrium. The polymorphisms of OPN and MGP were not significantly associated with primary knee osteoarthritis in the codominant, dominant, and recessive models ( p  > 0.05). Our study suggests that there are no associations between OPN and MGP polymorphisms with primary knee osteoarthritis in Mexican population.