Prospective study for the development of emulsion systems containing natural oil products

Copaiba oil, when used as anti-inflammatory and anti-infective agent, presents two major problems: i) low absorption and bioavailability and ii) an unpleasant taste. Once an appropriate emulsion was achieved, the samples were prepared using different surfactant binary mixtures to obtain a range of H...

Full description

Saved in:
Bibliographic Details
Published inJournal of drug delivery science and technology Vol. 22; no. 4; pp. 367 - 372
Main Authors Xavier-Júnior, F.H., Silva, K.G.H., Farias, I.E.G., Morais, A.R.V., Alencar, E.N., Araujo, I.B., Oliveira, A.G., Egito, E.S.T.
Format Journal Article
LanguageEnglish
Published Paris Elsevier B.V 2012
Editions de santé
Subjects
Bioavailability
Biological and medical sciences
Copaiba oil
Cosmetics
Drug delivery
Emulsion
General pharmacology
Hydrophilic
Inflammation
lipophilic balance
Medical sciences
Oil
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Pseudo-ternary phase diagram
Stability analysis
Surfactants
Taste
Copaiba oil
Hydrophilic
Stability analysis
Emulsion
Pseudo-ternary phase diagram
lipophilic balance
Oil
Stability
Pharmaceutical technology
Phase diagram
Hydrophilic lipophilic balance
Copaiba oil Hydrophilic-lipophilic balance
Physicochemical properties
Online AccessGet full text

Cover

More Information
Summary:Copaiba oil, when used as anti-inflammatory and anti-infective agent, presents two major problems: i) low absorption and bioavailability and ii) an unpleasant taste. Once an appropriate emulsion was achieved, the samples were prepared using different surfactant binary mixtures to obtain a range of HLB values between 4.5 and 16.5. The HLB value of copaiba oil was 14.8; this system has been stable for more than one year, and the pseudo-ternary diagrams were useful to describe the component proportions. These results indicated that the copaiba oil emulsion might be a promising vehicle for topical delivery of drugs and active cosmetic ingredients.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:1773-2247
DOI:10.1016/S1773-2247(12)50061-4