Case report: Effectiveness of brexpiprazole and esketamine/ketamine combination: A novel therapeutic strategy in five cases of treatment-resistant depression
A significant proportion of patients with treatment-resistant depression do not attain functional recovery despite administration of multiple steps of pharmacotherapeutic strategies. This highlights the elusiveness of meeting unmet needs in existing pharmacotherapies for treatment-resistant depressi...
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Published in | Frontiers in psychiatry Vol. 13; p. 890099 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Frontiers Media S.A
22.07.2022
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Subjects | |
Online Access | Get full text |
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Summary: | A significant proportion of patients with treatment-resistant depression do not attain functional recovery despite administration of multiple steps of pharmacotherapeutic strategies. This highlights the elusiveness of meeting unmet needs in existing pharmacotherapies for treatment-resistant depression. There is accumulating evidence that antidepressant agents involving the glutamatergic system such as brexpiprazole and esketamine/ketamine have more rapid onset of action and potentially improved effectiveness as an augmentation therapy in treatment-resistant depression. This case series aimed to report five complex cases of unipolar and bipolar treatment-resistant depression where conventional treatment strategies were inadequate in managing high risk suicidal behavior and achieving functional recovery. We discussed further the possible synergistic mechanisms of the novel combination strategy of brexpiprazole and esketamine/ketamine, clinical and patient factors that influenced treatment response, challenges with this combination strategy and implications for future practice and research. |
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Bibliography: | ObjectType-Case Study-2 SourceType-Scholarly Journals-1 content type line 23 ObjectType-Report-1 These authors share senior authorship Reviewed by: Chun Yang, The First Affiliated Hospital of Nanjing Medical University, China; Kenji Hashimoto, Chiba University, Japan Edited by: Lucie Bartova, Medical University of Vienna, Austria These authors share first authorship This article was submitted to Psychopharmacology, a section of the journal Frontiers in Psychiatry |
ISSN: | 1664-0640 1664-0640 |
DOI: | 10.3389/fpsyt.2022.890099 |