Idiopathic dysgeusia; an open trial of alpha lipoic acid (ALA) therapy

We selected two homogenous groups, each of 22 patients with idiopathic dysgeusia, an altered perception of taste, matched for age and sex, for an open trial of alpha lipoic acid compared with placebo. The 22 patients in the study group were treated with alpha lipoic acid for 2 months. The 22 patient...

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Published inInternational journal of oral and maxillofacial surgery Vol. 31; no. 6; pp. 625 - 628
Main Authors Femiano, F., Scully, C., Gombos, F.
Format Journal Article
LanguageEnglish
Published Amsterdam Elsevier Ltd 01.12.2002
Elsevier
Subjects
Adolescent
Adult
Aged
Analysis of Variance
Antioxidants - therapeutic use
Biological and medical sciences
Burning Mouth Syndrome - drug therapy
Burning Mouth Syndrome - physiopathology
Carboxymethylcellulose Sodium - therapeutic use
Case-Control Studies
Cranial nerves. Spinal roots. Peripheral nerves. Autonomic nervous system. Gustation. Olfaction
Cross-Over Studies
Dentistry
dysgeusia
Dysgeusia - drug therapy
Dysgeusia - physiopathology
Ent. Stomatology
Female
Follow-Up Studies
Humans
Linear Models
lipoic acid
Male
Medical sciences
Middle Aged
Nervous system (semeiology, syndromes)
Neurology
neuropathy
Pharmacology. Drug treatments
Placebos
Thioctic Acid - therapeutic use
Tongue Diseases - drug therapy
Tongue Diseases - physiopathology
neuropathy
dysgeusia
lipoic acid
Human
Lipoic acid
Nervous system diseases
Chemotherapy
Treatment
Dysgeusia
Idiopathic
Clinical trial
Neurological disorder
Taste disorder
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Summary:We selected two homogenous groups, each of 22 patients with idiopathic dysgeusia, an altered perception of taste, matched for age and sex, for an open trial of alpha lipoic acid compared with placebo. The 22 patients in the study group were treated with alpha lipoic acid for 2 months. The 22 patients in the control group were treated for 2 months with carboxymethylcellulose. The latter group was then treated with alpha lipoic acid for 2 months. The results showed significant symptomatic improvements compared with placebo, in both groups of patients with dysgeusia treated with alpha lipoic acid, suggesting that idiopathic dysgeusia may be a neuropathy comparable to the burning mouth syndrome.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:0901-5027
1399-0020
DOI:10.1054/ijom.2002.0276