7-Chloro-4-(Phenylselanyl) Quinoline with Memory Enhancer Action in Aging Rats: Modulation of Neuroplasticity, Acetylcholinesterase Activity, and Cholesterol Levels

• Published in: Molecular neurobiology Vol. 56; no. 9; pp. 6398 - 6408
• Main Authors: Barth, Anelise, Vogt, Ane G., dos Reis, Angélica S., Pinz, Mikaela P., Krüger, Roberta, Domingues, William B., Alves, Diego, Campos, Vinicius F., Pinton, Simone, Paroul, Natália, Wilhelm, Ethel A., Luchese, Cristiane
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.09.2019; Springer Nature B.V
• Subjects: Acetylcholinesterase; Acetylcholinesterase - metabolism; Aging; Animals; Behavioral plasticity; Biomedical and Life Sciences; Biomedicine; Cell adhesion & migration; Cell adhesion molecules; Cell Biology; Cerebral cortex; Cholesterol; Cholesterol - blood; Cholesterol - metabolism; Cholinergic transmission; Cognitive ability; Exploratory behavior; Locomotion - drug effects; Locomotor activity; Male; Memory - drug effects; Neural cell adhesion molecule; Neural Cell Adhesion Molecules - metabolism; Neural plasticity; Neurobiology; Neurology; Neuromodulation; Neuronal Plasticity - drug effects; Neurosciences; Open-field behavior; Organoselenium Compounds - chemistry; Organoselenium Compounds - pharmacology; Pattern recognition; Polysialyltransferase; Quinolines - chemistry; Quinolines - pharmacology; Rats, Wistar; Rodents; Sialyltransferases - metabolism; Synaptic plasticity; Learning; Aging; Quinoline; Selenium; Memory; Plasticity
• ISSN: 0893-7648; 1559-1182
• DOI: 10.1007/s12035-019-1530-5

This study investigated the effect of 7-chloro-4-(phenylselanyl) quinoline (4-PSQ) to restore the cognitive impairment caused by aging in male Wistar rats. Moreover, modulation of neuroplasticity markers, acetylcholinesterase (AChE) activity, and cholesterol levels was performed. Aged rats were intragastrically treated with 4-PSQ (5 mg/kg) for 7 days. Animals were tested in behavioral tasks, and then plasma (to determine cholesterol levels), hippocampus, and cerebral cortex (to determine neural cell adhesion molecule (NCAM) and polysialyltransferase (PST) levels, and AChE activity) were removed. Our findings demonstrated that treatment of aged rats with 4-PSQ restored short-term and long-term memories in the object recognition tests. 4-PSQ treatment did not restore exploratory activity (rearings) but partially restored locomotor activity (crossings) reduced by aging in the open-field test. Moreover, the compound restored the reduction in the NCAM and PST levels, and AChE activity in cerebral structures, as well as the increase in the plasma cholesterol levels, caused by aging in rats. In conclusion, 4-PSQ restored cognitive impairment caused by aging in rats by modulating synaptic plasticity, cholinergic system, and cholesterol levels.