Pulmonary protective effects of hyberbaric oxygen and N-acetylcysteine treatment in necrotizing pancreatitis

• Published in: Physiological research Vol. 55; no. 1; pp. 25 - 32
• Main Authors: Balkan, A, Balkan, M, Yasar, M, Korkmaz, A, Erdem, O, Kiliç, S, Kutsal, O, Bilgic, H
• Format: Journal Article
• Language: English
• Published: Czech Republic Institute of Physiology 2006
• Subjects: Acetylcysteine - therapeutic use; Animals; Ceruletide; Glutathione Peroxidase - metabolism; Hyperbaric Oxygenation; Lung - drug effects; Lung - metabolism; Lung - pathology; Male; Malondialdehyde - metabolism; Oxidative Stress; Pancreatitis, Acute Necrotizing - etiology; Pancreatitis, Acute Necrotizing - pathology; Pancreatitis, Acute Necrotizing - therapy; Rats; Rats, Sprague-Dawley; Respiratory Distress Syndrome - etiology; Respiratory Distress Syndrome - pathology; Respiratory Distress Syndrome - prevention & control; Superoxide Dismutase - metabolism
• ISSN: 0862-8408; 1802-9973
• DOI: 10.33549/physiolres.930765

The purpose of this study is to analyze the protective effect of combining N-acetylcysteine (NAC) and hyberbaric oxygen (HBO) treatment in the lung tissue during acute pancreatitis. Sixty Sprague-Dawley male rats were randomly divided into five groups; Group I; Control group (n=12), Group II; pancreatitis group (n=12), Group III; pancreatitis + NAC treatment group (n=12), Group IV; pancreatitis + HBO treatment group (n=12), Group V; pancreatitis + HBO + NAC treatment group (n=12). HBO was applied postoperatively for 5 days, twice a day at 2.5 fold absolute atmospheric pressure for 90 min. Lung tissue was obtained for measuring malondialdehyde (MDA), superoxide dismutase (Cu/Zn-SOD) and glutathione peroxidase (GSH-Px) levels along with histopathological tissue examinations. This study showed that all three treated groups (HBO alone, NAC alone and combined HBO+NAC treatment) had pulmonary protective effects during acute necrotizing pancreatitis.