The splice is right

Current drug discovery efforts focus on proteins because of their ability to form stable, structured pockets. A recent study demonstrates that targeting stable, structured bioactive RNA motifs, such as autocatalytic introns, may provide a novel method of expanding druggability and selectivity.

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Bibliographic Details
Published inNature chemical biology Vol. 14; no. 12; pp. 1068 - 1069
Main Author Palacino, James
Format Journal Article
LanguageEnglish
Published New York Nature Publishing Group US 01.12.2018
Nature Publishing Group
Subjects
631/326/41
631/92/500
631/92/507
631/92/613
Biochemical Engineering
Biochemistry
Biology
Bioorganic Chemistry
Biosynthesis
Carbon
Cell Biology
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Drug discovery
Engineering
Enzymes
Exons
Genes
Infections
Introns
Metabolism
Natural products
News & Views
news-and-views
Proteins
Ribonucleic acid
RNA
RNA Splicing
Selectivity
Online AccessGet full text

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More Information
Summary:Current drug discovery efforts focus on proteins because of their ability to form stable, structured pockets. A recent study demonstrates that targeting stable, structured bioactive RNA motifs, such as autocatalytic introns, may provide a novel method of expanding druggability and selectivity.
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ISSN:1552-4450
1552-4469
DOI:10.1038/s41589-018-0147-8