Growth Induction of Solid Ehrlich Ascitic Carcinoma in Mice after Proton Irradiation of Tumor Cells Ex Vivo

• Published in: Doklady. Biochemistry and biophysics Vol. 511; no. 1; pp. 151 - 155
• Main Authors: Balakin, V. E., Rozanova, O. M., Smirnova, E. N., Belyakova, T. A., Strelnikova, N. S., Smirnov, A. V., Shemyakov, A. E.
• Format: Journal Article
• Language: English
• Published: Moscow Pleiades Publishing 01.08.2023; Springer Nature B.V
• Subjects: Animals; Ascites; Biochemistry; Biological and Medical Physics; Biomedical and Life Sciences; Biophysics; Carcinoma; Carcinoma, Ehrlich Tumor - pathology; Carcinoma, Ehrlich Tumor - radiotherapy; Growth rate; Inoculation; Life Sciences; Mice; Molecular Biology; Protons; Radiation; Solid tumors; Tumor cells; protons; tumor growth; ex vivo; mice; Ehrlich ascites carcinoma
• ISSN: 1607-6729; 1608-3091
• DOI: 10.1134/S1607672923700229

This study presents data on the growth rate and frequency of induction of the solid form of Ehrlich’s ascites carcinoma (EAC) in mice in the short and long term after inoculation of ascitic cells irradiated ex vivo with a proton beam in the dose range of 30–150 Gy. It was shown that the growth rate of solid tumors after inoculation of irradiated cells ex vivo coincided with the growth of tumors in the control group. The frequency of tumor induction in mice after inoculation of EAC cells irradiated at a dose of 30 Gy was 80%, 60 Gy—60%, 90 Gy—25%, and 120 Gy—10%; at irradiation at a dose of 150 Gy, no tumors appeared during the entire observation period. Thus, we determined the dose of proton radiation required to eliminate tumor cells and/or signaling factors that can lead to the induction of tumor growth of EAC in mice.