All-trans -retinoic acid–induced scrotal ulcerations in a patient with acute promyelocytic leukemia

Induction therapy with all-trans -retinoic acid has been shown to improve the outcome of patients with acute promyelocytic leukemia, although some side effects occur. Dry skin and lips are among the most common cutaneous side effects. We report a case of scrotal ulcerations induced by all-trans -ret...

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Bibliographic Details
Published inJournal of the American Academy of Dermatology Vol. 43; no. 2; pp. 316 - 317
Main Authors Esser, Adam C., Nossa, Robert, Shoji, Toru, Sapadin, Allen N.
Format Journal Article
LanguageEnglish
Published New York, NY Mosby, Inc 01.08.2000
Elsevier
Subjects
Antineoplastic Agents - adverse effects
Biological and medical sciences
Drug toxicity and drugs side effects treatment
Genital Diseases, Male - chemically induced
Humans
Leukemia, Promyelocytic, Acute - drug therapy
Male
Medical sciences
Middle Aged
Pharmacology. Drug treatments
Scrotum
Toxicity: skin, dermoskeleton
Tretinoin - adverse effects
Ulcer - chemically induced
Antineoplastic agent
Human
Promyelocytic leukemia
Skin disease
Toxicity
Acute
Retinoid
Malignant hemopathy
Case study
Scrotum
Skin
Ulceration
Tretinoin
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Summary:Induction therapy with all-trans -retinoic acid has been shown to improve the outcome of patients with acute promyelocytic leukemia, although some side effects occur. Dry skin and lips are among the most common cutaneous side effects. We report a case of scrotal ulcerations induced by all-trans -retinoic acid in an American patient; to our knowledge this is the first such case reported. (J Am Acad Dermatol 2000;43:316-7.)
ISSN:0190-9622
1097-6787
DOI:10.1067/mjd.2000.106354