GLP-1 and GLP-2 Levels are Correlated with Satiety Regulation After Roux-en-Y Gastric Bypass: Results of an Exploratory Prospective Study

• Published in: Obesity surgery Vol. 27; no. 3; pp. 703 - 708
• Main Authors: Cazzo, Everton, Pareja, José Carlos, Chaim, Elinton Adami, Geloneze, Bruno, Barreto, Maria Rita Lazzarini, Magro, Daniéla Oliveira
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.03.2017; Springer Nature B.V
• Subjects: Adolescent; Adult; Aged; Appetite Regulation; Female; Gastric Bypass - methods; Gastrointestinal surgery; Glucagon-Like Peptide 1 - blood; Glucagon-Like Peptide 2 - blood; Humans; Hunger - physiology; Male; Medicine; Medicine & Public Health; Middle Aged; Obesity; Obesity, Morbid - blood; Obesity, Morbid - metabolism; Obesity, Morbid - surgery; Original Contributions; Peptides; Postoperative Period; Prospective Studies; Satiation - physiology; Surgery; Weight Loss - physiology; Young Adult; Obesity; Glucagon-like peptides; Bariatric surgery; Gastric bypass; Satiety response
• ISSN: 0960-8923; 1708-0428
• DOI: 10.1007/s11695-016-2345-3

Background Changes in satiety regulation are known to play a pivotal role in the weight loss effects of Roux-en-Y gastric bypass (RYGB) and the mechanisms by which these changes occur are not entirely known. There are previous reports of the influence of GLP-1 to cause enhancement of satiation, but in regard to GLP-2, it remains unclear. This study aimed to determine whether there is a correlation between the levels of GLP-1 and GLP-2 and satiety regulation following RYGB. Materials and Methods An exploratory prospective cohort study was made which enrolled 11 individuals who underwent RYGB and were followed-up for 12 months. GLP-1 and GLP-2 levels were determined before and after surgery and correlated with visual analogue scale scores for satiety. Results GLP-2 AUC after standard meal tolerance test (MTT) was significantly higher following surgery (945.3 ± 449.1 versus 1787.9 ± 602.7; p  = 0.0037). Postoperatively, GLP-1 AUC presented a significant negative correlation with the mean score obtained in the first question of the visual analogue scale (“how hungry do you feel?”) ( p  = 0.008); GLP-2 AUC presented a significant positive correlation with the mean score of the third (“how full do you feel?”) question, and a significant positive correlation with the mean score achieved in the fourth question (“how much do you think you can eat?”), ( p  = 0.005 and p  = 0.042, respectively). Conclusion GLP-1 and GLP-2 were significantly correlated with satiety assessment within this sample. Further research is necessary to confirm these findings.