MyD88-dependent interleukin-10 production from regulatory CD11b+ Gr-1high cells suppresses development of acute cerulein pancreatitis in mice

Highlights ► MyD88−/− mice developed severer cerulein-induced pancreatitis. ► CD11b+ Gr-1high cells emerge in the pancreas of cerulein-administered mice. ► IL-10-producing CD11b+ Gr-1high cells emerge independently of commensal bacteria.

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Bibliographic Details
Published inImmunology letters Vol. 148; no. 2; pp. 172 - 177
Main Authors Koike, Yuji, Kanai, Takanori, Saeki, Keita, Nakamura, Yuji, Nakano, Masaru, Mikami, Yohei, Yamagishi, Yoshiyuki, Nakamoto, Nobuhiro, Ebinuma, Hirotoshi, Hibi, Toshifumi
Format Journal Article
LanguageEnglish
Published Elsevier B.V 17.12.2012
Subjects
Allergy and Immunology
Cerulein
IL-10
Macrophage
MyD88
Pancreatitis
MDSC
Pancreatitis
myeloid gene 88
Cerulein
MyD88
IL-10
APC
myeloid-derived suppressor cell
antigen presenting cell
TLR
wild-type
WT
Toll-like receptor
Macrophage
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Summary:Highlights ► MyD88−/− mice developed severer cerulein-induced pancreatitis. ► CD11b+ Gr-1high cells emerge in the pancreas of cerulein-administered mice. ► IL-10-producing CD11b+ Gr-1high cells emerge independently of commensal bacteria.
Bibliography:ObjectType-Article-1
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ObjectType-Feature-2
content type line 23
ISSN:0165-2478
1879-0542
DOI:10.1016/j.imlet.2012.08.008