Circulating Cytokines in Patients with Cat Scratch Disease

Levels of circulating interleukin (IL)-2, IL-6, and IL-10, measured by enzyme-linked immunosorbent assay, were significantly higher in patients with cat scratch disease (CSD) than in healthy control subjects; no induction of IL-12 was observed, and levels of interferon-γ and IL-4 were generally not...

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Published inClinical infectious diseases Vol. 33; no. 6; pp. e54 - e56
Main Authors Papadopoulos, Nikolaos G., Gourgiotis, Dimitrios, Bossios, Apostolos, Fretzayas, Andrew, Moustaki, Maria, Karpathios, Themistocles
Format Journal Article
LanguageEnglish
Published United States The University of Chicago Press 15.09.2001
Subjects
Antibodies, Bacterial - blood
Bartonella henselae - immunology
Case-Control Studies
Cat-Scratch Disease - diagnosis
Cat-Scratch Disease - immunology
Child
Cytokines - blood
Female
Humans
Immunity, Cellular
Interferon-gamma - blood
Interleukin-10 - blood
Interleukin-12 - blood
Interleukin-2 - blood
Interleukin-4 - blood
Interleukin-6 - blood
Male
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Summary:Levels of circulating interleukin (IL)-2, IL-6, and IL-10, measured by enzyme-linked immunosorbent assay, were significantly higher in patients with cat scratch disease (CSD) than in healthy control subjects; no induction of IL-12 was observed, and levels of interferon-γ and IL-4 were generally not detectable. This is the first report showing increased circulating cytokine levels in patients with CSD. The induction of these mediators can partly explain some clinical and pathological features of the disease.
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ISSN:1058-4838
1537-6591
DOI:10.1086/322596