Microwave initiated reactions: Pechmann coumarin synthesis, Biginelli reaction, and acylation

Coumarins were synthesized by a solvent-free energy-saving procedure. An energy-efficient protocol has been developed for solvent-free reactions that are mildly exothermic but not spontaneous. The exothermic reaction mixture—on several g-scale—is exposed for about 30 s to low power (about 200 W) mic...

Full description

Saved in:
Bibliographic Details
Published inTetrahedron letters Vol. 47; no. 14; pp. 2423 - 2425
Main Authors Manhas, Maghar S., Ganguly, Subhendu N., Mukherjee, Somdatta, Jain, Amit K., Bose, Ajay K.
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 03.04.2006
Elsevier
Subjects
Chemistry
Chemistry, Organic
Coumarins
Energy-efficient reaction
Microwave chemistry
Physical Sciences
Science & Technology
Solvent-free reaction
Coumarins
Microwave chemistry
Energy-efficient reaction
Solvent-free reaction
GREEN CHEMISTRY
Online AccessGet full text

Cover

More Information
Summary:Coumarins were synthesized by a solvent-free energy-saving procedure. An energy-efficient protocol has been developed for solvent-free reactions that are mildly exothermic but not spontaneous. The exothermic reaction mixture—on several g-scale—is exposed for about 30 s to low power (about 200 W) microwaves and then the microwave oven is switched off. After this short burst of energy, the exothermic reaction gets initiated and proceeds on its own to completion. A number of coumarins were synthesized by the Pechmann reaction using this strategy.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2006.01.147