Genome‐wide detection of changes in allelic frequency in Landrace pigs selected for resistance to mycoplasma pneumonia of swine

• Published in: Animal science journal Vol. 94; no. 1; pp. e13827 - n/a
• Main Authors: Uemoto, Yoshinobu, Ichinoseki, Kasumi, Matsumoto, Toshimi, Oka, Nozomi, Takamori, Hironori, Kadowaki, Hiroshi, Shibata, Chihiro, Suzuki, Eisaku, Okamura, Toshihiro, Aso, Hisashi, Kitazawa, Haruki, Satoh, Masahiro, Uenishi, Hirohide, Suzuki, Keiichi
• Format: Journal Article
• Language: English
• Published: Australia Blackwell Publishing Ltd 01.01.2023
• Subjects: allele frequency change; Alleles; Animal husbandry; Animals; Breeding; Change detection; closed‐line breeding; gene dropping; Gene frequency; Gene Frequency - genetics; Gene mapping; Genetic structure; Genome-Wide Association Study - veterinary; Genomes; Genomic analysis; Genomics; Hogs; Landrace pigs; Livestock breeding; Nucleotides; Phenotype; Pneumonia; Pneumonia of Swine, Mycoplasmal - genetics; Polymorphism, Single Nucleotide - genetics; Population structure; Quantitative trait loci; Quantitative Trait Loci - genetics; random genetic drift; Single-nucleotide polymorphism; Swine; Swine - genetics; Swine Diseases; gene dropping; Landrace pigs; random genetic drift; allele frequency change; closed-line breeding
• ISSN: 1344-3941; 1740-0929
• DOI: 10.1111/asj.13827

Closed‐pig line breeding could change the genetic structure at a genome‐wide scale because of the selection in a pig breeding population. We investigated the changes in population structure among generations at a genome‐wide scale and the selected loci across the genome by comparing the observed and expected allele frequency changes in mycoplasma pneumonia of swine (MPS)‐selected pigs. Eight hundred and seventy‐four Landrace pigs, selected for MPS resistance without reducing average daily gain over five generations, had 37,299 single nucleotide polymorphisms (SNPs) and were used for genomic analyses. Regarding population structure, individuals in the first generation were the most widely distributed and then converged into a specific group, as they were selected over five generations. For allele frequency changes, 96 and 14 SNPs had higher allele frequency changes than the 99.9% and 99.99% thresholds of the expected changes, respectively. These SNPs were evenly spread across the genome, and a few of these selected regions overlapped with previously detected quantitative trait loci for MPS and immune‐related traits. Our results indicated that the considerable changes in allele frequency were identified in many regions across the genome by closed‐pig line breeding based on estimated breeding value.