Evaluation of hemodynamic changes using near‐infrared spectroscopy in patients with tic‐related obsessive–compulsive disorder

• Published in: Psychiatry and clinical neurosciences Vol. 75; no. 6; pp. 191 - 199
• Main Authors: Mukai, Keiichiro, Matsuura, Naomi, Miyauchi, Masahiro, Hashimoto, Takuya, Yamanishi, Kyosuke, Maebayashi, Kensei, Hayashida, Kazuhisa, Matsunaga, Hisato
• Format: Journal Article
• Language: English
• Published: Melbourne John Wiley & Sons Australia, Ltd 01.06.2021; Wiley Subscription Services, Inc
• Subjects: dorsolateral prefrontal cortex; Executive function; frontal polar cortex; Hemodynamics; Infrared spectroscopy; near‐infrared spectroscopy; Obsessive compulsive disorder; obsessive–compulsive and related disorders; Prefrontal cortex; Spectrum analysis; tic‐related obsessive–compulsive disorder; near-infrared spectroscopy; obsessive-compulsive and related disorders; tic-related obsessive-compulsive disorder; dorsolateral prefrontal cortex; frontal polar cortex
• ISSN: 1323-1316; 1440-1819
• DOI: 10.1111/pcn.13207

Aim A tic‐related specifier is included in the DSM‐5 diagnostic criteria to identify a clinically specific obsessive–compulsive disorder (OCD) subtype. The current study sought to evaluate hemodynamic changes during executive function tasks among OCD patients with and without a lifetime history of tic disorder (TD) and healthy controls, and to investigate the relation between brain activation and clinical variables in each group using structured equation modeling. Methods Twenty‐nine OCD patients diagnosed according to the DSM‐IV‐TR and 15 healthy controls were recruited. Patients were divided into two groups according to the presence or absence of a lifetime history of TD (TD+, n = 11; TD−, n = 18). Prefrontal hemodynamic changes were measured using multi‐channel near‐infrared spectroscopy during the Verbal Fluency Task, Trail‐Making Task, and Tower of London (ToL) Task. Results There were significant brain activation differences in the frontopolar cortex between OCD patients with and without TD during Verbal Fluency Task and ToL performance. Brain activation in the dorsolateral prefrontal cortex (DLPFC) during the ToL Task in OCD patients with TD exerted a direct causal effect on the severity of compulsions. In addition, we detected a direct causal effect of the severity of obsessions in OCD patients without TD on brain activation in the DLPFC during the ToL Task. Conclusion Brain activation in the frontopolar cortex exhibits different hemodynamics depending on the task, and DLPFC function may play a different role in the neural basis of developing OCD symptoms between OCD patients with and without TD.