Fabrication of a Novel Biocompatible Magnetic Biomaterial with Hyperthermia Potential
Preparation and characterization of a novel biocompatible magnetic biomaterial having hyperthermia potential is reported in this study. Fe3+ and Ni2+ (2:1) cosubstituted hydroxyapatite nanoparticles were synthesized by simple wet precipitation method followed by freeze‐drying which on heat treatment...
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Published in | Journal of the American Ceramic Society Vol. 97; no. 4; pp. 1115 - 1122 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Columbus
Blackwell Publishing Ltd
01.04.2014
Wiley Subscription Services, Inc |
Subjects | |
Online Access | Get full text |
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Summary: | Preparation and characterization of a novel biocompatible magnetic biomaterial having hyperthermia potential is reported in this study. Fe3+ and Ni2+ (2:1) cosubstituted hydroxyapatite nanoparticles were synthesized by simple wet precipitation method followed by freeze‐drying which on heat treatment at 1150°C yielded the above mentioned biocompatible magnetic biomaterial composed of hydroxyapatite and β‐tricalcium phosphate along with nickel ferrite. The product was characterized by X‐ray diffraction, Fourier transform infrared spectroscopy, and transmission electron microscope along with composition analysis. The magnetic behavior was analyzed by vibrating sample magnetometer and biocompatibility was assessed by testing the toxicity on Hela cells using MTT assay. The hyperthermia potential of the material was studied using induction heating. The prepared material has the potential to generate sufficient heat that could be easily controlled by magnetic field parameters and amount of sample. Hence, it can be a potential candidate for making implantable thermoseed for hyperthermia treatment. |
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Bibliography: | ArticleID:JACE12746 UGC India - No. 41-1013/2012 SR ark:/67375/WNG-JSJDZNC1-X Periyar University CSIR istex:1824B78791D37E367CB7038C7E62A0E584C7C888 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 |
ISSN: | 0002-7820 1551-2916 |
DOI: | 10.1111/jace.12746 |