Syntheses and Biological Activities of Danicalipin A Derivatives

Synthesis of three derivatives of danicalipin A, tetrachloride, trisulfate and a fluorescent probe was achieved through Wittig reaction strategy. Toxicity of the derivatives against brine shrimp (Artemia salina) as also investigated to provide useful information for the biological activity; i) less...

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Published inChemistry & biodiversity Vol. 20; no. 6; pp. e202300400 - n/a
Main Authors Umezawa, Taiki, Maeda, Takeshi, Akiyama, Takuya, Iman Prakoso, Nurcahyo, Jerin Mehjabin, Jakia, Okino, Tatsufumi, Matsuda, Fuyuhiko
Format Journal Article
LanguageEnglish
Published Switzerland Wiley Subscription Services, Inc 01.06.2023
Subjects
Artemia
Biological activity
Brines
chlorosulfolipids
Fluorescent indicators
fluorescent probe
Shrimps
structure–activity relationship
Toxicity
structure-activity relationship
fluorescent probe
chlorosulfolipids
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Summary:Synthesis of three derivatives of danicalipin A, tetrachloride, trisulfate and a fluorescent probe was achieved through Wittig reaction strategy. Toxicity of the derivatives against brine shrimp (Artemia salina) as also investigated to provide useful information for the biological activity; i) less chloride derivative showed similar toxicity to danicalipin A, ii) the amphiphilic property, a characteristic feature of danicalipin A, was crucial because trisulfate considerably decreased the toxicity and iii) fluorescent derivative kept brine shrimp toxicity of danicalipin A.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1612-1872
1612-1880
DOI:10.1002/cbdv.202300400