Relationship between oseteoporosis with fatty infiltration of paraspinal muscles based on QCT examination

• Published in: Journal of bone and mineral metabolism Vol. 40; no. 3; pp. 518 - 527
• Main Authors: Li, Xiangwen, Xie, Yuxue, Lu, Rong, Zhang, Yuyang, Tao, Hongyue, Chen, Shuang
• Format: Journal Article
• Language: English
• Published: Singapore Springer Nature Singapore 01.05.2022
• Subjects: Medicine; Medicine & Public Health; Metabolic Diseases; Original Article; Orthopedics; Osteoporosis; Fat infiltration; Bone density; Paraspinal muscles
• ISSN: 0914-8779; 1435-5604
• DOI: 10.1007/s00774-022-01311-z

Introduction To investigate the correlation between paraspinal muscles features and osteoporosis in lumbar spine. Materials and methods A total of 367 subjects who underwent quantitative computed tomography (QCT) examination were enrolled in this study. QCT pro workstation was used to obtain the mean bone mineral density (BMD) of the lower lumbar spine. Fat fraction (FF) and cross-section area (CSA) of the paraspinal muscles at the corresponding levels were measured. All participants were divided into normal, osteopenia, and osteoporosis groups. One-way ANOVA and independent samples t tests were performed to compare differences between groups. Pearson and Spearman correlation coefficients and partial correlation analysis after controlling for confounding factors were used to analyze the correlation between BMD and paraspinal muscles measurements. Results Among the 367 participants included, 116 were in the normal group, 130 in the osteopenia group and 121 in the osteoporosis group. There were significant differences among the three groups for the mean and multifidus FF. BMD showed negative correlations with the FF of the paraspinal muscles. Multifidus and mean FF showed the best correlation ( r  = − 0.654, − 0.777). There were also significant differences in the mean and multifidus FF between different age groups, while after controlling for confounding factors, there was no correlation between age and FF of the paraspinal muscles. Conclusion This preliminary study demonstrated the association of BMD with fatty infiltration of paraspinal muscles. Different muscles might have specific effects in different sex and age groups.