A Matched Case-Control Study of Preoperative Biliary Drainage in Patients with Pancreatic Adenocarcinoma: Routine Drainage Is Not Justified

• Published in: Journal of gastrointestinal surgery Vol. 13; no. 12; pp. 2163 - 2169
• Main Authors: Mezhir, James J., Brennan, Murray F., Baser, Raymond E., D’Angelica, Michael I., Fong, Yuman, DeMatteo, Ronald P., Jarnagin, William R., Allen, Peter J.
• Format: Journal Article
• Language: English
• Published: New York Springer-Verlag 01.12.2009; Springer Nature B.V
• Subjects: 2009 SSAT Poster Presentation; Adenocarcinoma - surgery; Adult; Aged; Aged, 80 and over; Bile Ducts - surgery; Blood Loss, Surgical; Case-Control Studies; Cholangiopancreatography, Endoscopic Retrograde; Drainage - adverse effects; Endoscopy, Digestive System; Female; Gastroenterology; Humans; Male; Medical research; Medicine; Medicine & Public Health; Middle Aged; Pancreatic Neoplasms - surgery; Pancreaticoduodenectomy; Postoperative Complications; Preoperative Care - adverse effects; Stents - adverse effects; Surgery; Biliary drainage; Pancreaticoduodenectomy; Complications; Pancreatic cancer
• ISSN: 1091-255X; 1873-4626
• DOI: 10.1007/s11605-009-1046-9

Background Preoperative biliary drainage (PBD) prior to pancreaticoduodenectomy (PD) continues to be routine in many centers despite retrospective and randomized data showing that PBD increases perioperative infectious complications. Methods Review of a prospectively maintained database identified 340 consecutive patients with pancreatic adenocarcinoma who underwent PD between 2000 and 2005. From this cohort, 94 PBD and 94 nonstented (no-PBD) patients were matched for age, gender, preoperative albumin, and bilirubin levels (PBD group: prestent bilirubin; no-PBD group: preoperative bilirubin). Results The majority of PBD patients (89%) underwent internal endoscopic biliary drainage. Stent-related complications occurred in 46 patients (23%) and resulted in a significant delay in time to resection. In the matched-pair comparison, there was more operative blood loss in PBD patients, but similar operative times, transfusions, and hospital stay. Bile cultures were positive in 82% of PBD patients versus 7% no PBD. There was a statistically significant increase in infectious complications including wound infections and intra-abdominal abscess in PBD patients, but equal incidence of anastomotic leak. Conclusions In this case-matched control study, PBD was associated with a stent-related complication rate of 23% and resulted in a twofold increase in postpancreatectomy infectious complications. The routine use of PBD remains unjustified.