Injectable polyoxazoline grafted hyaluronic acid thermoresponsive hydrogels for biomedical applications

• Published in: Journal of materials chemistry. B, Materials for biology and medicine Vol. 12; no. 11; pp. 287 - 2817
• Main Authors: Morel, Morgane, Madau, Mathieu, Le Cerf, Didier, Dulong, Virginie, Groo, Anne-Claire, Malzert-Fréon, Aurélie, Picton, Luc
• Format: Journal Article
• Language: English
• Published: England Royal Society of Chemistry 13.03.2024
• Subjects: Biomedical materials; Chemical Sciences; Copolymers; Graft copolymers; Hyaluronic Acid; Hydrogels; Injectability; Mechanical properties; Modulus of elasticity; Polymers; Polyoxazolines; Stability; Temperature
• ISSN: 2050-750X; 2050-7518
• DOI: 10.1039/d3tb02108d

Injectable thermosensitive hydrogels based on hyaluronic acid (HA) grafted with lower critical solution temperature (LCST) polyoxazoline (copolymers of poly(isopropyl- co -butyl oxazoline)) or P(iPrOx- co -BuOx) have been elaborated with tunable solution/gel temperature transitions and gel state elastic modulus. A suitable HA- g -P(iPrOx- co -BuOx-67/33)-0.10 sample with an iPrOx/BuOx ratio of 67/33, a polymerization degree (DP) of 25, a substitution degree (DS) of 10%, and displaying thermally induced gelling character with elastic ( G ′) and viscous ( G ′′) moduli crossover points at 25 °C and a G ′ at 37 °C around 80 Pa has been chosen for medical application. Hydrogels obtained with HA- g -P(iPrOx- co -BuOx-67/33)-0.10 exhibited high stability at 37 °C and excellent injectability properties with full and quick reversibility. The incorporation of a secondary network (HA), until 35 wt%, into the thermosensitive hydrogel also demonstrated very good stability and injectability. Injectable thermosensitive hydrogels based on hyaluronic acid (HA) grafted with lower critical solution temperature (LCST) polyoxazoline (copolymers of poly(isopropyl- co -butyl oxazoline)) or P(iPrOx- co -BuOx) have been elaborated with tunable solution/gel temperature transitions and gel state elastic modulus.