Genomics of Mycobacterium bovis

The imminent completion of the genome sequence of Mycobacterium bovis will reveal the genetic blueprint for this most successful pathogen. Comparative analysis with the genome sequences of M. tuberculosis and M. bovis BCG promises to expose the genetic basis for the phenotypic differences between th...

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Bibliographic Details
Published inTuberculosis (Edinburgh, Scotland) Vol. 81; no. 1-2; p. 157
Main Authors Gordon, S V, Eiglmeier, K, Garnier, T, Brosch, R, Parkhill, J, Barrell, B, Cole, S T, Hewinson, R G
Format Journal Article
LanguageEnglish
Published Scotland 01.01.2001
Subjects
Bacterial Proteins - genetics
Bacterial Typing Techniques
BCG Vaccine - genetics
Gene Deletion
Genome, Bacterial
Mycobacterium bovis - genetics
Mycobacterium bovis - pathogenicity
Mycobacterium tuberculosis - genetics
Mycobacterium tuberculosis - pathogenicity
Phenotype
Polymorphism, Genetic - genetics
Vaccines, Attenuated - genetics
Virulence
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Summary:The imminent completion of the genome sequence of Mycobacterium bovis will reveal the genetic blueprint for this most successful pathogen. Comparative analysis with the genome sequences of M. tuberculosis and M. bovis BCG promises to expose the genetic basis for the phenotypic differences between the tubercle bacilli, offering unparalleled insight into the virulence factors of the M. tuberculosis complex. Initial analysis of the sequence data has already revealed a novel deletion from M. bovis, as well as identifying variation in members of the PPE family of proteins. As the study of bacterial pathogenicity enters the postgenomic phase, the genome sequence of M. bovis promises to serve as a cornerstone of mycobacterial genetics.
ISSN:1472-9792
1873-281X
DOI:10.1054/tube.2000.0269