Determination of absolute configuration using single crystal X-ray diffraction

Single crystal X-ray crystallography is the most powerful structural method for the determination of the 3D structures of molecules. While the results of a routine diffraction experiment readily provide unambiguous determination of the relative configuration of all stereogenic centers in the molecul...

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Bibliographic Details
Published inMethods in molecular biology (Clifton, N.J.) Vol. 1055; p. 149
Main Authors Albright, Abigail L, White, Jonathan M
Format Journal Article
LanguageEnglish
Published United States 01.01.2013
Subjects
Biological Products - chemistry
Crystallography, X-Ray - methods
Stereoisomerism
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Summary:Single crystal X-ray crystallography is the most powerful structural method for the determination of the 3D structures of molecules. While the results of a routine diffraction experiment readily provide unambiguous determination of the relative configuration of all stereogenic centers in the molecule, determination of absolute configuration is more challenging. This chapter provides some helpful tips towards increasing the chances of success in the determination of the absolute configuration of a chiral, enantiomerically pure natural product using X-ray crystallography.
ISSN:1940-6029
DOI:10.1007/978-1-62703-577-4_11