Markedly elevated levels of vascular endothelial growth factor, fibroblast growth factor, and interleukin 6 in Meigs syndrome

• Published in: American journal of obstetrics and gynecology Vol. 184; no. 3; pp. 354 - 355
• Main Authors: Abramov, Yoram, Anteby, Shaoul O., Fasouliotis, Sozos J., Barak, Vivian
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA Mosby, Inc 01.02.2001; Elsevier
• Subjects: Ascites - metabolism; Ascitic Fluid - metabolism; Biological and medical sciences; Endothelial Growth Factors - blood; Endothelial Growth Factors - metabolism; Female; Female genital diseases; Fibroblast growth factor; Fibroblast Growth Factors - blood; Fibroblast Growth Factors - metabolism; Gynecology. Andrology. Obstetrics; Histocytochemistry; Humans; Hysterectomy; Immunoenzyme Techniques; interleukin 6; Interleukin-6 - blood; Interleukin-6 - metabolism; Lymphokines - blood; Lymphokines - metabolism; Medical sciences; Meigs syndrome; Meigs Syndrome - blood; Meigs Syndrome - metabolism; Meigs Syndrome - surgery; Middle Aged; Pleural Effusion, Malignant - metabolism; Tumors; vascular endothelial growth factor; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Fibroblast growth factor; interleukin 6; Meigs syndrome; vascular endothelial growth factor; Human; Hydrothorax; Effusion; Respiratory disease; Cytokine; Fibroma; Female genital diseases; Peritoneal fluid; Blood plasma; Case study; Interleukin 6; Ovarian diseases; Ovary; Vascular endothelium growth factor; Polypeptide; Abdominal disease; Pleural disease; Complication; Female; Benign neoplasm; Ascites; Growth factor
• ISSN: 0002-9378; 1097-6868
• DOI: 10.1067/mob.2001.110028

Analysis of serum and peritoneal and pleural fluid from a patient with Meigs’ syndrome revealed high levels of vascular endothelial growth factor, fibroblast growth factor, and interleukin 6. Serum levels declined after removal of the ovarian tumor, along with resolution of ascites and hydrothorax. These findings suggest the involvement of these vasoactive factors in ascites and pleural fluid formation in Meigs’ syndrome. (Am J Obstet Gynecol 2001;184:354-5.)