Expression and clinical value of the soluble major histocompatibility complex class I-related chain A molecule in the serum of patients with renal tumors

• Published in: Genetics and molecular research Vol. 14; no. 2; pp. 7233 - 7240
• Main Authors: Zhao, Y-K, Jia, C-M, Yuan, G-J, Liu, W, Qiu, Y, Zhu, Q-G
• Format: Journal Article
• Language: English
• Published: Brazil 01.01.2015
• Subjects: Aged; Biomarkers, Tumor - blood; Biomarkers, Tumor - genetics; Case-Control Studies; Female; Gene Expression; Histocompatibility Antigens Class I - blood; Histocompatibility Antigens Class I - genetics; Humans; Kidney Neoplasms - blood; Kidney Neoplasms - diagnosis; Kidney Neoplasms - genetics; Kidney Neoplasms - immunology; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Recurrence, Local - blood; Neoplasm Recurrence, Local - diagnosis; Neoplasm Recurrence, Local - genetics; Neoplasm Recurrence, Local - immunology; Neoplasm Staging; Neoplasms - blood; Neoplasms - diagnosis; Neoplasms - genetics; Neoplasms - immunology; Solubility; Tumor Escape - genetics
• ISSN: 1676-5680; 1676-5680
• DOI: 10.4238/2015.June.29.16

We investigated the expression and clinical value of the soluble major histocompatibility complex class I-related chain A (sMICA) molecule in the serum of patients with renal tumors. Sixty patients diagnosed with renal tumors were enrolled in the experimental group, whereas 20 healthy volunteers served as the control group. The sMICA levels were measured via enzyme-linked immunosorbent assay, and the results were analyzed in combination with data from pathol-ogy examination. The experimental group had a statistically significant higher sMICA level (P < 0.05) than the control group. The sMICA level was higher in patients with malignant tumors than in those with be-nign tumors. We also observed a positive relationship among different tumor-node-metastasis (TNM) pathological stages with more advanced diseases exhibiting higher sMICA levels. As a tumor-associated antigen, MICA has a close relationship with renal tumorigenesis and immune es-cape. Our results indicated that sMICA levels were related to tumor pathol-ogy, TNM stage, and metastasis. Therefore, sMICA might be a potential marker for tumor characteristics, prognosis, and recurrence prediction.