Effects of gabapentin, pregabalin and gastroretentive gabapentin on simulated driving, daytime sedation and cognition

Randomized Phase I study examining the effects of gabapentinoids gabapentin, pregabalin and gastroretentive gabapentin on simulated driving performance, sedation and cognitive function in healthy volunteers (n = 32). Driving attentiveness, sleepiness and cognition were evaluated prior to subjects re...

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Bibliographic Details
Published inPain management Vol. 8; no. 4; pp. 297 - 306
Main Authors Schmidt, Peter, Rao, Srinivas
Format Journal Article
LanguageEnglish
Published England Future Medicine Ltd 01.07.2018
Subjects
Analgesics
Anesthesia
cognition
Cognition & reasoning
driving performance
Drug dosages
Drug therapy
gabapentinoids
gastroretentive gabapentin
Pain
Pain management
postherpetic neuralgia
sedation
Side effects
Simulation
Traffic accidents & safety
United States > US
driving performance
postherpetic neuralgia
gastroretentive gabapentin
cognition
gabapentinoids
sedation
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Summary:Randomized Phase I study examining the effects of gabapentinoids gabapentin, pregabalin and gastroretentive gabapentin on simulated driving performance, sedation and cognitive function in healthy volunteers (n = 32). Driving attentiveness, sleepiness and cognition were evaluated prior to subjects receiving study doses. Blood samples were collected during each treatment. Subjects receiving gastroretentive gabapentin showed less change in variation in lateral lane position (p = 0.0275), less tremor (p = 0.0304) and fewer vision disturbances compared with gabapentin (p = 0.0177). Statistically significant decrease in One Card Learning Test performance was observed after treatment with gastroretentive gabapentin. Gastroretentive gabapentin demonstrated reduced driving impairment and lower scores on key neurotoxicity measures. Further studies in patients with postherpetic neuralgia are needed. Clinical trial number: NCT03179345
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1758-1869
1758-1877
DOI:10.2217/pmt-2018-0005