The expression and prognostic value of SOX2, β-catenin and survivin in esophageal squamous cell carcinoma

• Published in: Future oncology (London, England) Vol. 15; no. 36; pp. 4181 - 4195
• Main Authors: Zhou, Ya-Xing, Liu, Qian, Wang, Hui, Ding, Fend, Ma, Yu-Qing
• Format: Journal Article
• Language: English
• Published: England Future Medicine Ltd 01.12.2019
• Subjects: Adult; Aged; Apoptosis; beta Catenin - genetics; Biomarkers, Tumor; Cancer therapies; Cell cycle; Cell division; Cell growth; Chemoradiotherapy; Chemotherapy; Chromosomes; Combined Modality Therapy; Cytoplasm; Deoxyribonucleic acid; DNA; Esophageal cancer; esophageal squamous cell carcinoma; Esophageal Squamous Cell Carcinoma - diagnosis; Esophageal Squamous Cell Carcinoma - genetics; Esophageal Squamous Cell Carcinoma - mortality; Esophageal Squamous Cell Carcinoma - therapy; Female; Gene Expression Regulation, Neoplastic; Genes; Genomes; Humans; Immunohistochemistry; Kaplan-Meier Estimate; Male; Medical prognosis; Medical research; Metastasis; Middle Aged; Mortality; Neoplasm Grading; Neoplasm Staging; Patients; Prognosis; Proteins; Radiation therapy; SOX2; SOXB1 Transcription Factors - genetics; Squamous cell carcinoma; survivin; Survivin - genetics; Tumors; β-catenin; China; SOX2; esophageal squamous cell carcinoma; survivin; β-catenin; immunohistochemistry; prognosis
• ISSN: 1479-6694; 1744-8301
• DOI: 10.2217/fon-2018-0884

We mainly explored the effect of SOX2, β-catenin and survivin on prognosis in esophageal squamous cell carcinoma. Immunohistochemistry was used to examine the expression of SOX2, β-catenin and survivin. χ test was used to analyze the relationship between proteins and clinicopathological parameters. Survival analysis was used to investigate the effect of three proteins on prognosis. SOX2 was related to lymph node metastasis (p = 0.004) and vascular invasion (p = 0.041). β-catenin was associated with depth of invasion (p = 0.014), lymph node metastasis (p = 0.032) and postoperative chemoradiotherapy (p < 0.001). Survivin was related to gender (p = 0.022) and nerve invasion (p = 0.014). There was a positive correlation between SOX2 and β-catenin. Patients with SOX2 and β-catenin overexpression had poor prognosis. Survivin-positive patients who received postoperative chemoradiotherapy had a short time. SOX2, β-catenin and survivin can be used as prognostic markers of esophageal squamous cell carcinoma.