Early NT-proBNP and MR-proANP associated with QoL 1 year after acutely decompensated heart failure: secondary analysis from the MOLITOR trial

Heart failure negatively impacts quality of life (QoL), which in turn contributes to an adverse long-term prognosis. We aimed at identifying biomarker trajectories after an episode of acutely decompensated heart failure (ADHF) that differ between patients showing average versus impaired QoL 1 year l...

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Published inBiomarkers in medicine Vol. 13; no. 17; pp. 1493 - 1507
Main Authors Zelenak, Christine, Chavanon, Mira-Lynn, Tahirovic, Elvis, Trippel, Tobias Daniel, Tscholl, Verena, Stroux, Andrea, Veskovic, Jovan, Apostolovic, Svetlana, Obradovic, Danilo, Zdravkovic, Marija, Loncar, Goran, Störk, Stefan, Herrmann-Lingen, Christoph, Düngen, Hans-Dirk
Format Journal Article
LanguageEnglish
Published England Future Medicine Ltd 01.12.2019
Subjects
ADHF
Anxiety
Biomarkers
Cardiovascular disease
Congestive heart failure
disease management
Dyspnea
Health surveys
Heart failure
Hospitals
Medical prognosis
Mental depression
Mortality
MR-proANP
NT-proBNP
Patients
Peptides
Population
prediction
QoL
Quality of life
Quantitative psychology
Questionnaires
Studies
support
United States > US
Germany
heart failure
NT-proBNP
MR-proANP
prediction
support
ADHF
QoL
disease management
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Summary:Heart failure negatively impacts quality of life (QoL), which in turn contributes to an adverse long-term prognosis. We aimed at identifying biomarker trajectories after an episode of acutely decompensated heart failure (ADHF) that differ between patients showing average versus impaired QoL 1 year later, thus allowing to predict impaired QoL. Biomarkers were repeatedly measured throughout the year in 104 ADHF patients. QoL was assessed at discharge and 1 year after ADHF. Logistic regression and receiver operating characteristic analyses were used to identify predictors of impaired QoL while controlling psychosocial confounders. MR-proANP predicted impaired physical and mental QoL. NT-proBNP measurements were important predictors for poor physical QoL. MR-proANP and NT-proBNP predict poor QoL after an epidode of ADHF. The trial is registered at as MOLITOR (IMpact of therapy optimisation On the Level of biomarkers in paTients with Acute and Decompensated ChrOnic HeaRt Failure) with unique identifier: NCT01501981.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ISSN:1752-0363
1752-0371
DOI:10.2217/bmm-2019-0083