Cardiac biochemical markers after cardioversion of atrial fibrillation or atrial flutter

• Published in: The American heart journal Vol. 140; no. 4; pp. 690 - 696
• Main Authors: Vikenes, Kjell, Omvik, Per, Farstad, Mikael, Nordrehaug, Jan Erik
• Format: Journal Article
• Language: English
• Published: New York, NY Mosby, Inc 01.10.2000; Elsevier
• Subjects: Adult; Aged; Aged, 80 and over; Atrial Fibrillation - blood; Atrial Fibrillation - physiopathology; Atrial Fibrillation - therapy; Atrial Flutter - blood; Atrial Flutter - physiopathology; Atrial Flutter - therapy; Biological and medical sciences; Biomarkers - blood; Creatine Kinase - blood; Diseases of the cardiovascular system; Electric Countershock; Female; Humans; Male; Medical sciences; Middle Aged; Myocardium - metabolism; Myoglobin - blood; Prognosis; Prospective Studies; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects); Troponin - blood; Human; Intensive cardiocirculatory care; Arrhythmia; Atrial fibrillation; Instrumentation therapy; Biological marker; Cardiovascular disease; Cardioversion; Exploration; Coronary heart disease; Myocardial disease; Excitability disorder; Differential diagnostic; Atrial flutter; Vascular disease; Troponin; Treatment; Ischemia; Heart disease; Myocardium; Evolution; Defibrillation
• ISSN: 0002-8703; 1097-6744
• DOI: 10.1067/mhj.2000.109646

Background Cardioversion or defibrillation of cardiac arrhythmias is often necessary in acutely ill cardiac patients. The electrical current may cause elevation of biochemical markers used to diagnose acute myocardial infarction. Therefore it is important to find cardiac markers with high specificity for myocardial necrosis. The purpose of this study was to assess the effects of elective cardioversion of atrial fibrillation or flutter on troponin T and I among conventional markers in patients with no evidence of acute ischemia. Methods and Results Fifty-seven consecutive patients underwent 1 to 4 direct current shocks (mean cumulative energy 407 J, range 100 to 920 J) under general anesthesia. At baseline, all had normal troponin levels; 50 patients (mean age 68 years, range 33 to 84 years) had normal cardiac enzymes and were included in the final analysis. Blood samples were drawn at baseline, and 1 to 2, 6 to 8, and 20 to 24 hours after cardioversion. The troponin levels were unaffected by cardioversion in all patients, whereas creatine kinase and myoglobin increased more than 10-fold. Creatine kinase MB mass and aspartate aminotransferase were above reference limits in 18% and 24% of patients, respectively, 20 to 24 hours after cardioversion. There was a significant association between elevated creatine kinase, myoglobin, and creatine kinase MB levels with cumulated energy delivered as well as when possible confounders such as age and sex were adjusted for. High international normalized ratio with warfarin use was associated with increased levels of creatine kinase, aspartate aminotransferase, lactate dehydrogenase, and myoglobin. Conclusions The increase of conventional biochemical markers after direct current cardioversion is positively associated with cumulative energy delivered and international normalized ratio (INR) values; neither influences levels of the cardiac troponins. (Am Heart J 2000;140:690-6.)