Vaccine-preventable anal infections by human papillomavirus among HIV-infected men who have sex with men

• Published in: Future microbiology Vol. 13; no. 13; pp. 1463 - 1472
• Main Authors: Giuliani, Massimo, Latini, Alessandra, Colafigli, Manuela, Benevolo, Maria, Rollo, Francesca, Zaccarelli, Mauro, Giuliani, Eugenia, Moretto, Domenico, Giglio, Amalia, Rezza, Giovanni, Cristaudo, Antonio, Donà, Maria G
• Format: Journal Article
• Language: English
• Published: England Future Medicine Ltd 01.10.2018
• Subjects: Adult; Age groups; anal; Anal Canal - virology; Anus Diseases - diagnosis; Anus Diseases - epidemiology; Anus Diseases - prevention & control; Anus Diseases - virology; Cancer; Cohort Studies; Deoxyribonucleic acid; Disease; DNA; Drug therapy; Enrollments; Family medical history; Gays & lesbians; Genotyping; HIV; HIV - genetics; HIV - immunology; HIV Infections - diagnosis; HIV Infections - epidemiology; HIV Infections - virology; Homosexuality, Male; HPV; Human immunodeficiency virus; Human papillomavirus; Human Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18 - immunology; Humans; Immunization; Immunology; Incidence; Infections; Male; Males; Mens health; MSM; Papillomaviridae - genetics; Papillomaviridae - immunology; Papillomavirus Infections - diagnosis; Papillomavirus Infections - epidemiology; Papillomavirus Infections - prevention & control; Papillomavirus Infections - virology; Population; Prevalence; Prospective Studies; Sexually Transmitted Diseases - diagnosis; Sexually Transmitted Diseases - epidemiology; Sexually Transmitted Diseases - prevention & control; Sexually Transmitted Diseases - virology; Vaccination; vaccine; Vaccines; Warts; Italy; vaccine; HIV; anal; MSM; HPV
• ISSN: 1746-0913; 1746-0921; 1746-0921
• DOI: 10.2217/fmb-2018-0149

HIV-infected men who have sex with men (MSM) show the highest prevalence of anal HPV infection. Anal prevalence of the HPVs targeted by the quadrivalent HPV vaccine (4vHPV) and nonavalent HPV vaccine (9vHPV) was estimated in this population. Anal specimens were collected from HIV-infected MSM attending a sexually transmitted infection/HIV center. Specimens were analyzed using the Linear Array HPV Genotyping Test. A total of 49.5 and 71.2% of the 313 enrolled MSM harbored at least one of the 4vHPV and 9vHPV types, respectively. A significantly decreasing trend was observed for the prevalence of both 4vHPV (p = 0.04) and 9vHPV types (p < 0.001) across age classes. A substantial proportion of HIV-infected MSM do not harbor a current anal infection with vaccine-preventable HPVs. The potential benefit of the 4vHPV versus 9vHPV vaccination in these subjects, including older MSM, should be investigated.