The postoperative platelet distribution width is useful for predicting the prognosis in patients with esophageal squamous cell carcinoma

• Published in: Surgery today (Tokyo, Japan) Vol. 50; no. 2; pp. 123 - 133
• Main Authors: Matsunaga, Tomoyuki, Saito, Hiroaki, Fukumoto, Yoji, Shimizu, Shota, Kono, Yusuke, Murakami, Yuki, Shishido, Yuji, Miyatani, Kozo, Yamamoto, Manabu, Tokuyasu, Naruo, Takano, Shuichi, Sakamoto, Teruhisa, Honjo, Soichiro, Fujiwara, Yoshiyuki
• Format: Journal Article
• Language: English
• Published: Singapore Springer Singapore 01.02.2020
• Subjects: Medicine; Medicine & Public Health; Original Article; Surgery; Surgical Oncology; Recurrence; Prognosis; Esophageal cancer; Platelet distribution width
• ISSN: 0941-1291; 1436-2813
• DOI: 10.1007/s00595-019-01860-3

Purpose The platelet distribution width (PDW) is reportedly useful as a prognostic indicator for some cancers. However, its prognostic significance in esophageal squamous cell carcinoma (ESCC) is unclear. Methods We enrolled 104 patients with thoracic ESCC, who underwent curative esophagectomy. Results Receiver operating curve analyses indicated that the optimal cut-off values of pre- and postoperative PDW were 16.9 and 17.0, respectively. The 5-year overall survival (OS) rate was significantly lower in patients with a high-preoperative PDW (≥ 16.9; 52.6%) than in those with a low-preoperative PDW (< 16.9; 61.0% P  = 0.045). The 5-year disease-specific survival (DSS) rates were 64.3% in patients with a high-preoperative PDW and 69.3% in those with a low-preoperative PDW ( P  = 0.13). Regarding the postoperative PDW, the 5-year OS rate was significantly lower in patients with a high-postoperative PDW (≥ 17.0; 35.7%) than in those with a low-postoperative PDW (< 17.0; 66.8% P  = 0.0017). The 5-year DSS rates were 52.2% in patients with a high-postoperative PDW and 73.2% in those with a low-postoperative PDW ( P  = 0.037). Finally, a multivariate analysis revealed that the postoperative PDW but not the preoperative PDW was an independent prognostic factor. Conclusions The postoperative PDW was useful for predicting the prognosis of patients with ESCC.