Orbital osteoclastoma of apparent extraskeletal origin in a pagetic patient: A case report

• Published in: Human pathology Vol. 31; no. 12; pp. 1527 - 1531
• Main Authors: Pecorella, Irene, Ciardi, Antonio, Amadeo, Giorgio, Baiocchini, Andrea, Marasco, Angela, Tondo, Ugo Di
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.12.2000; Elsevier
• Subjects: Biological and medical sciences; Diseases of the osteoarticular system; Female; Giant Cell Tumor of Bone - diagnostic imaging; Giant Cell Tumor of Bone - etiology; Giant Cell Tumor of Bone - pathology; Giant Cell Tumor of Bone - surgery; Humans; Magnetic Resonance Imaging; Medical sciences; Middle Aged; Ophthalmology; Orbital Neoplasms - diagnostic imaging; Orbital Neoplasms - etiology; Orbital Neoplasms - pathology; Orbital Neoplasms - surgery; Osteitis Deformans - complications; Osteitis Deformans - diagnostic imaging; Osteitis Deformans - pathology; Osteoporosis. Osteomalacia. Paget disease; Soft Tissue Neoplasms - diagnostic imaging; Soft Tissue Neoplasms - etiology; Soft Tissue Neoplasms - pathology; Soft Tissue Neoplasms - surgery; Tomography, X-Ray Computed; Tumors and pseudotumors of the eye, orbit, eyelid, lacrimal apparatus; Human; Immunohistochemistry; Paget disease of bone; Radiodiagnosis; Diseases of the osteoarticular system; Orbit(eye) disease; Bone disease; Orbit(eye); Nuclear magnetic resonance imaging; Case study; Radiography; Pathology; Eye disease; Giant cell tumor; Medical imagery; Tumor; Adult; Female; Extraosseous; Computerized axial tomography
• ISSN: 0046-8177; 1532-8392
• DOI: 10.1053/hupa.2000.20411

A large mass in the right orbit, causing proptosis, ptosis of the right upper eyelid, and limitation to eye movements, was surgically removed from a 51-year-old woman suffering from Paget's bone disease (PBD). Histologically, a giant cell tumor of the bone (osteoclastoma) was diagnosed. No bony involvement was apparent either operatively, microscopically, or on preoperative computed tomographic scans. The neoplasm has not recurred in a 3-year follow-up. In addition to the fact that osteoclastoma complicating PBD is rare, the extraskeletal origin of the tumor is a matter of interest and can be tentatively explained by an unusually powerful systemic stimulus acting on circulating osteoclast precursors. H UM P ATHOL 31:1527-1531.