2-Hydroxypropyl-β-cyclodextrin encapsulates dimethyl disulfide producing a controlled release formulation

• Published in: The Science of the total environment Vol. 773; p. 145293
• Main Authors: Hao, Baoqiang, Ren, Lirui, Huang, Bin, Tang, Xiujun, Cheng, Hongyan, Yan, Dongdong, Li, Yuan, Cao, Aocheng, Ouyang, Canbin, Wang, Qiuxia
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15.06.2021
• Subjects: 2-Hydroxypropyl-beta-cyclodextrin; Control efficiency; Controlled release; Delayed-Action Preparations; Disulfides; Fumigant; HP-β-CD; Humans; Inclusion complex; Spectroscopy, Fourier Transform Infrared; Fumigant; Control efficiency; HP-β-CD; Inclusion complex; Controlled release
• ISSN: 0048-9697; 1879-1026
• DOI: 10.1016/j.scitotenv.2021.145293

Dimethyl disulfide (DMDS), a soil fumigant, is an effective, broad-spectrum compound that often replaces bromomethane (MB) in the prevention and treatment of soil-borne diseases. However, the disadvantages of DMDS include toxicity, volatility, pungent odor, risk of human exposure, and environmental pollution. Cyclodextrin (CD) has been widely used as a carrier of chemicals in many industries due to its functional advantages and safety. In this study, a DMDS-controlled release formulation was developed by encapsulating DMDS in the cavity of 2-hydroxypropyl-β-cyclodextrin (HP-β-CD). This formulation reduced DMDS usage and production costs. Orthogonal experimental design, Fourier transform infrared (FT-IR), Scanning electron microscopy (SEM), Thermal gravity analysis (TGA) characterization, efficacy comparison, safety, and other aspects of the evaluation showed that under the best preparation conditions, the encapsulation rate was 81.49%. The efficacy of DMDS@HP-β-CD was similar to unformulated DMDS. The efficacy duration of the formulation was about two times longer than DMDS, and it was safer to use. This study reveals a cyclodextrin-DMDS formulation with reduced toxicity, longer duration, environmental safety and sustainability. [Display omitted] •DMDS was encapsulated in HP-β-CD forming controlled release formulation.•DMDS@HP-β-CD exhibited better bioactivity to soil-borne diseases and nematodes.•HP-β-CD is very easy to degrade and do not cause environmental pressure.•DMDS inclusion complex was safe to use and did not cause harm to crops.