Mammalian homologues of the Drosophila eye specification genes

The Drosophila compound eye is specified by the simultaneous and interdependent activity of transcriptional regulatory genes from four families: PAX6 (eyeless, twin of eyeless, eyegone), EYA (eyes absent), SIX (sine oculis, Optix) and DACH (dachshund). Mammals have homologues of all these genes, and...

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Bibliographic Details
Published inSeminars in cell & developmental biology Vol. 12; no. 6; pp. 475 - 484
Main Author Hanson, Isabel M
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.12.2001
Subjects
Animals
Conserved Sequence
DACH / EYA / eyeless / PAX6 / SIX
DACH gene
Drosophila
Drosophila - genetics
EYA gene
Eye - embryology
Eye - growth & development
Eye Proteins - genetics
Gene Expression Regulation
Mammalia
Mammals - genetics
Mice
pax-6 gene
PAX6 gene
Protein Structure, Tertiary - physiology
Sequence Homology
Six gene
DACH / EYA / eyeless / PAX6 / SIX
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Summary:The Drosophila compound eye is specified by the simultaneous and interdependent activity of transcriptional regulatory genes from four families: PAX6 (eyeless, twin of eyeless, eyegone), EYA (eyes absent), SIX (sine oculis, Optix) and DACH (dachshund). Mammals have homologues of all these genes, and many of them are expressed in the embryonic or adult eye, but the functional relationships between them are currently much less clear than in Drosophila. Nevertheless, mutations in the mammalian genes highlight their requirement both within and outside the eye in embryos and adults, and emphasize that they can be deployed in many different contexts.
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ISSN:1084-9521
1096-3634
DOI:10.1006/scdb.2001.0271