A novel stimuli-responsive hydrogel for K +-induced controlled-release

• Published in: Polymer (Guilford) Vol. 51; no. 7; pp. 1648 - 1653
• Main Authors: Mi, Peng, Ju, Xiao-Jie, Xie, Rui, Wu, Han-Guang, Ma, Jiang, Chu, Liang-Yin
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 24.03.2010; Elsevier
• Subjects: Applied sciences; Biological and medical sciences; Controlled-release; Exact sciences and technology; General pharmacology; Hydrogels; Ion-recognition; Medical sciences; Organic polymers; Pharmaceutical technology. Pharmaceutical industry; Pharmacology. Drug treatments; Physicochemistry of polymers; Properties and characterization; Solution and gel properties; Ion-recognition; Hydrogels; Controlled-release; Swelling; Potassium ion; Control release polymer; Temperature effect; Crown compound; Drug carrier; Acrylamide derivative copolymer; Experimental study; Cyanocobalamin; Lateral group; Colloidal gel; Medium effect; Preparation; Kinetics; Radical copolymerization; Release
• ISSN: 0032-3861; 1873-2291
• DOI: 10.1016/j.polymer.2010.02.018

A novel family of stimuli-responsive smart hydrogel is developed in this study for K +-induced self-regulated controlled-release, which is featured with isothermally K +-induced pulse-release mode at a certain temperature due to the isothermally K +-induced shrinking behavior of the hydrogel by recognizing the increase of K + concentration in the environment. The proposed poly( N-isopropylacrylamide- co-benzo-15-crown-5-acrylamide) hydrogel is composed of crown ether 15-crown-5 as ion-signal sensing receptor and poly( N-isopropylacrylamide) as actuator. The selective formation of stable 2:1 “host-guest” complexation between the crown ether 15-crown-5 and potassium ion drives the polymeric network of the hydrogel to shrink; as a result, the hydrogel exhibits especial and selective response to potassium ions. A K +-recognition pulse-release performance of loaded drug from the fabricated hydrogel is achieved by using the K +-induced isothermal shrinkage property of the hydrogel. The proposed hydrogel provides a new mode of K +-recognition volume change for stimuli-responsive smart actuators, which is highly attractive for targeting drug delivery systems, biomedical devices, and sensors and so on. [Display omitted]