Pleiotropic Effects of Herbs Characterized with Blood-Activating and Stasis-Resolving Functions on Angiogenesis

Accumulative evidences have underpinned the nature candidates from Chinese medicine （CM）, particularly CM served as blood activating and stasis resolving （BASR, Huoxue Huayu in Chinese） by targeting tumor-associated angiogenesis. However, recent experiment research on the therapeutic angiogenesis by...

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Bibliographic Details
Published inChinese journal of integrative medicine Vol. 22; no. 10; pp. 795 - 800
Main Author 陶丽 王生 赵杨 王爱云 张蕾 阮君山 范方田 刘玉萍 李尧 岳志强 钱文慧 陈文星 陆茵
Format Journal Article
LanguageEnglish
Published Berlin/Heidelberg Springer Berlin Heidelberg 01.10.2016
Subjects
Angiogenesis Inhibitors - chemistry
Angiogenesis Inhibitors - therapeutic use
Animals
Antineoplastic Agents - therapeutic use
Drugs, Chinese Herbal - chemistry
Drugs, Chinese Herbal - therapeutic use
Humans
Medicine
Medicine & Public Health
Models, Biological
Neovascularization, Pathologic - blood
Neovascularization, Pathologic - drug therapy
Review
中药
基础环
多效性
活血化瘀
相互作用
缺血性疾病
肿瘤血管生成
静止状态
pathological angiogenesis
Chinese medicine
physiological angiogenesis
blood activating and stasis resolving
anti-angiogenesis
pro-angiogenesis
arteriogenesis
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Summary:Accumulative evidences have underpinned the nature candidates from Chinese medicine （CM）, particularly CM served as blood activating and stasis resolving （BASR, Huoxue Huayu in Chinese） by targeting tumor-associated angiogenesis. However, recent experiment research on the therapeutic angiogenesis by BASR-CM attracts wide attention and discussion. This opinion review focused on the underlying link between two indications and anticipated that （1） BASR-CM might emphasize on a balanced multi-cytokines network interaction; （2） BASR-CM might address on the nature of diseases prior to differently affecting physiological and pathological angiogenesis; （3） BASR-CM might mainly act on perivascular cells, either promotes arteriogenesis by increasing arteriogenic factors in ischemic diseases, or simultaneously keep a quiescent vasculature to impede angiogenesis in tumor context.
Bibliography:11-4928/R
TAO Li1, WANG Sheng1, ZHAO Yang1, WANG Ai-yun 1.2, ZHANG Lei3, RUAN Jun-shan4, FAN Fang-tian5, LIU Yu-ping1, LI Yao1, YUE Zhi-qiang1, QIAN Wen-hui6, CHEN Wen-xing1,2, and LU Yin1,2（ 1. Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing （210023）, China; 2. Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine Prevention and Treatment of Tumor, Nanjing University of Chinese Medicine, Nanjing （210023）, China; 3. Department of Pharmacy, Provincial Hospital Affiliated to Anhui Medical University, Hefei （230001）, China; 4. Fujian Provincial Hospital, Clinical College of Fujian Medical University, Fuzhou （350001）, China; 5. Department of Pharmacology, Hanlin College, Nanjing University of Chinese Medicine, Taizhou Jiangsu Province （225300）, China; 6. Department of Pharmaceutics, Jinling Hospital, Nanjing University School of Medicine, Nanjing （210002）, China）
blood activating and stasis resolving, Chinese medicine, pro-angiogenesis, anti-angiogenesis,physiological angiogenesis, pathological angiogenesis, arteriogenesis
Accumulative evidences have underpinned the nature candidates from Chinese medicine （CM）, particularly CM served as blood activating and stasis resolving （BASR, Huoxue Huayu in Chinese） by targeting tumor-associated angiogenesis. However, recent experiment research on the therapeutic angiogenesis by BASR-CM attracts wide attention and discussion. This opinion review focused on the underlying link between two indications and anticipated that （1） BASR-CM might emphasize on a balanced multi-cytokines network interaction; （2） BASR-CM might address on the nature of diseases prior to differently affecting physiological and pathological angiogenesis; （3） BASR-CM might mainly act on perivascular cells, either promotes arteriogenesis by increasing arteriogenic factors in ischemic diseases, or simultaneously keep a quiescent vasculature to impede angiogenesis in tumor context.
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1672-0415
1993-0402
DOI:10.1007/s11655-015-2405-x