Clerodane diterpenoids from Dodonaea viscosa and their inhibitory effects on ATP citrate lyase
Six undescribed clerodane diterpenoids, dodovisins A−F, together with nine known ones, were isolated from the aerial parts of Dodonaea viscosa (L.) Jacq. Their structures were elucidated by extensive spectroscopic techniques, X-ray crystallographic analysis, and ECD calculation. Dodovisins A and B p...
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Published in | Phytochemistry (Oxford) Vol. 183; p. 112614 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
OXFORD
Elsevier Ltd
01.03.2021
Elsevier |
Subjects | |
Online Access | Get full text |
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Summary: | Six undescribed clerodane diterpenoids, dodovisins A−F, together with nine known ones, were isolated from the aerial parts of Dodonaea viscosa (L.) Jacq. Their structures were elucidated by extensive spectroscopic techniques, X-ray crystallographic analysis, and ECD calculation. Dodovisins A and B possess a rare carbon skeleton featuring a bicyclo[6.2.0]decane motif. Dodovisins C−E represent the first clerodane diterpenoids with a 4(5 → 19)-abeo-2,4,10(1)-triene moiety. Dodovisins A, E, and strictic acid showed potent inhibitory activities against ATP citrate lyase.
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•Fifteen clerodane diterpenoids were isolated and identified from Dodonaea viscosa.•Six diterpenoids with structural diversity are undescribed.•Some of the diterpenoids showed potent inhibition against ATP citrate lyase. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0031-9422 1873-3700 |
DOI: | 10.1016/j.phytochem.2020.112614 |