Clerodane diterpenoids from Dodonaea viscosa and their inhibitory effects on ATP citrate lyase

• Published in: Phytochemistry (Oxford) Vol. 183; p. 112614
• Main Authors: Lei, Chun, Wang, Xiao-Hang, Liu, Yi-Nan, Zhao, Ting, Hu, Zhu, Li, Jing-Ya, Hou, Ai-Jun
• Format: Journal Article
• Language: English
• Published: OXFORD Elsevier Ltd 01.03.2021; Elsevier
• Subjects: ATP Citrate (pro-S)-Lyase; ATP citrate Lyase; Biochemistry & Molecular Biology; Clerodane diterpenoids; Diterpenes, Clerodane - pharmacology; Dodonaea viscosa (L.) Jacq; Dodovisins A−F; Life Sciences & Biomedicine; Molecular Structure; Plant Sciences; Sapindaceae; Science & Technology; Dodonaea viscosa (L.) Jacq; Dodovisins A−F; ATP citrate Lyase; Sapindaceae; Clerodane diterpenoids; STRICTIC ACID; DERIVATIVES; Dodovisins A-F; CONSTITUENTS
• ISSN: 0031-9422; 1873-3700
• DOI: 10.1016/j.phytochem.2020.112614

Six undescribed clerodane diterpenoids, dodovisins A−F, together with nine known ones, were isolated from the aerial parts of Dodonaea viscosa (L.) Jacq. Their structures were elucidated by extensive spectroscopic techniques, X-ray crystallographic analysis, and ECD calculation. Dodovisins A and B possess a rare carbon skeleton featuring a bicyclo[6.2.0]decane motif. Dodovisins C−E represent the first clerodane diterpenoids with a 4(5 → 19)-abeo-2,4,10(1)-triene moiety. Dodovisins A, E, and strictic acid showed potent inhibitory activities against ATP citrate lyase. [Display omitted] •Fifteen clerodane diterpenoids were isolated and identified from Dodonaea viscosa.•Six diterpenoids with structural diversity are undescribed.•Some of the diterpenoids showed potent inhibition against ATP citrate lyase.