Distinctive flow pattern of wall shear stress and oscillatory shear index: similarity and dissimilarity in ruptured and unruptured cerebral aneurysm blebs

• Published in: Journal of neurosurgery Vol. 117; no. 4; p. 774
• Main Authors: Kawaguchi, Tomohiro, Nishimura, Shinjitsu, Kanamori, Masayuki, Takazawa, Hiroki, Omodaka, Shunsuke, Sato, Kenya, Maeda, Noriko, Yokoyama, Yoko, Midorikawa, Hiroshi, Sasaki, Tatsuya, Nishijima, Michiharu
• Format: Journal Article
• Language: English
• Published: United States 01.10.2012
• Subjects: Adult; Aged; Aged, 80 and over; Aneurysm, Ruptured - diagnostic imaging; Aneurysm, Ruptured - pathology; Aneurysm, Ruptured - physiopathology; Biomechanical Phenomena; Cerebral Angiography; Cohort Studies; Female; Hemodynamics - physiology; Humans; Hydrodynamics; Intracranial Aneurysm - diagnostic imaging; Intracranial Aneurysm - pathology; Intracranial Aneurysm - physiopathology; Magnetic Resonance Imaging; Male; Middle Aged; Oscillometry; Regional Blood Flow - physiology; Retrospective Studies; Stress, Mechanical
• ISSN: 1933-0693
• DOI: 10.3171/2012.7.jns111991

The difference in the hemodynamics of wall shear stress (WSS) and oscillatory shear index (OSI) between ruptured and unruptured aneurysms is not well understood. The authors investigated the hemodynamic similarities and dissimilarities in ruptured and thin-walled unruptured aneurysm blebs. Magnetic resonance imaging-based fluid dynamics analysis was used to calculate WSS and OSI, and hemodynamic and intraoperative findings were compared. The authors also compared ruptured and unruptured thin-walled blebs for the magnitude of WSS and OSI. Intraoperatively, 13 ruptured and 139 thin-walled unruptured aneurysm blebs were identified. Twelve of the ruptured (92.3%) and 124 of the unruptured blebs (89.2%) manifested low WSS and high OSI. The degree of WSS was significantly lower in ruptured (0.49 ± 0.12 Pa) than in unruptured (0.64 ± 0.15 Pa; p < 0.01) blebs. Ruptured and unruptured blebs shared a distinctive pattern of low WSS and high OSI. The degree of WSS at the rupture site was significantly lower than in the unruptured thin-walled blebs.