Prenylated flavonoids from Commiphora opobalsamum stem bark

• Published in: Phytochemistry (Oxford) Vol. 141; pp. 80 - 85
• Main Authors: El-Gamal, Ali A., Al-Massarani, Shaza M., Abdel-Mageed, Wael M., El-Shaibany, Amina, Al-Mahbashi, Hassan M., Basudan, Omer A., Badria, Farid A., Al-Said, Mansour S., Abdel-Kader, Maged S.
• Format: Journal Article
• Language: English
• Published: OXFORD Elsevier Ltd 01.09.2017; Elsevier
• Subjects: Antineoplastic Agents, Phytogenic - chemistry; Antineoplastic Agents, Phytogenic - isolation & purification; Biochemistry & Molecular Biology; Burseraceae; Commiphora - chemistry; Commiphora opobalsamum; Cytotoxic activity; Drug Screening Assays, Antitumor; Flavonoids; Flavonoids - chemistry; Flavonoids - isolation & purification; Hep G2 Cells; Humans; Life Sciences & Biomedicine; MCF-7 Cells; Molecular Structure; Plant Bark - chemistry; Plant Sciences; Prenylated flavonoids; Prenylation; Science & Technology; Flavonoids; Prenylated flavonoids; Burseraceae; Commiphora opobalsamum; Cytotoxic activity
• ISSN: 0031-9422; 1873-3700
• DOI: 10.1016/j.phytochem.2017.05.014

A phytochemical study on the stem bark of Commiphora opobalsamum looking for cytotoxic compounds afforded eleven flavonoids, including six previously undescribed prenylated congeners, comophorin A–E, and comophoroside A. The structures of the isolated compounds were elucidated on the basis of spectroscopic evidences and correlated with known compounds. Isolated compounds were biologically evaluated using in vitro cytotoxicity MTT-based assay against two cancer cell lines; namely human hepato-cellular carcinoma (HepG-2) and human breast adenocarcinoma (MCF-7). Comophoroside A revealed to retain the strongest cytotoxic activity against MCF-7 and HepG-2 cell lines with IC50 values of 8 and 12 μg/mL, respectively. [Display omitted] •Six undescribed prenylated flavonoids were isolated from Commiphora opobalsamum.•The structures of compounds were identified by extensive NMR and HRESIMS.•Comophoroside A displayed strong cytotoxic activity against two cancer cell lines.