Central Nervous System International Prognostic Index Impacts Overall Survival in Diffuse Large B-cell Lymphoma Treated with R-Chop in a third Level Cancer Center from Mexico: A Survey of 642 Patients

• Published in: Revista de investigacion clinica Vol. 73; no. 4; pp. 231 - 237
• Main Authors: Solís-Armenta, Rubén, Cacho-Díaz, Bernardo, Gutiérrez-Hernández, Olga, Candelaria-Hernández, Myrna
• Format: Journal Article
• Language: English
• Published: Mexico 12.04.2021
• ISSN: 0034-8376
• DOI: 10.24875/RIC.21000010

Central nervous system international prognosis index (CNS-IPI) is validated in European and the USA cancer databases. However, no validation has been done in Mexican population. The objective of the study was to assess the impact of the CNS-IPI on central nervous system (CNS) relapse and survival in Mexican patients with diffuse large B-cell lymphoma (DLBCL). In this retrospective analysis, clinical, biochemical, and histological variables and the CNS-IPI were analyzed. Six hundred and forty-two patients with DBLCL were included in the study. The mean ± SD age was 56.8 ± 14.9 years. Most had an ECOG of 0-1: 75% (n = 484) had absence of B-symptoms and advanced disease (clinical stage: III-IV, n = 433, 67.4%). According to the CNS-IPI, almost one-half were in the low-risk category. According to the CNS-IPI, CNS relapse rate was 1.36% (95% CI: 83.2-92.8), 3.1% (95% CI: 132.4-162.8), and 7.4% (95% CI 61-91) for patients in the low-, intermediate-, and high-risk categories, respectively. The median overall survival in the high-risk group (CNS-IPI) was 22 months, and it has not been achieved after 80 months of follow-up for the other groups. CNS-IPI was associated with survival; therefore, we propose its use as a prognostic tool for prospective validation.