High expression of COX5B is associated with poor prognosis in breast cancer

• Published in: Future oncology (London, England) Vol. 13; no. 19; pp. 1711 - 1719
• Main Authors: Gao, Shui-Ping, Sun, He-Fen, Fu, Wen-Yan, Li, Liang-Dong, Zhao, Yang, Chen, Meng-Ting, Jin, Wei
• Format: Journal Article
• Language: English
• Published: England Future Medicine Ltd 01.08.2017
• Subjects: Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Breast cancer; Breast Neoplasms - genetics; Breast Neoplasms - mortality; Breast Neoplasms - pathology; Chemotherapy; COX5B; Cytochrome; Disease; disease-free survival; Electron Transport Complex IV - genetics; Electron Transport Complex IV - metabolism; Female; Gene Expression; Humans; IHC; Immunohistochemistry; Medical prognosis; Middle Aged; Mitochondria; Neoplasm Grading; Neoplasm Metastasis; Neoplasm Staging; Patients; Prognosis; Prostate cancer; Senescence; Surgery; Survival Analysis; breast cancer; disease-free survival; COX5B; IHC; mitochondria
• ISSN: 1479-6694; 1744-8301; 1744-8301
• DOI: 10.2217/fon-2017-0058

Cytochrome c oxidase subunit VB (COX5B), a subunit of mammalian COX, takes roles in COX assembling and functions. Online database predicts high transcription may be associated with worse disease-free survival (DFS). However, the clinical implications of COX5B in breast cancer remain unclear. We carried out immunohistochemistry on tissue microarrays of 244 patients with invasive ductal breast carcinoma to detected COX5B expression. Our results suggest that COX5B protein level might be associated with tumor size. COX5B overexpression indicated a worse DFS (p < 0.05) in breast cancer. Furthermore, high COX5B expression may act as an independent factor for worse DFS in breast cancer. Conclusions: Cumulatively, our findings suggest that COX5B might serve as an important prognostic factor for breast cancer.