Investigating the susceptibility of mice to a bacterial challenge after intravenous exposure to durable nanoparticles

The goal of this study was to determine whether bacterial clearance in a rodent model would be impaired upon exposure to gold, silver or silica nanoparticles (NPs). Mice received weekly injections of NPs followed by a challenge of (LM). On days 3 and 10 after LM injections, the animals were sacrific...

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Bibliographic Details
Published inNanomedicine (London, England) Vol. 12; no. 17; pp. 2097 - 2111
Main Authors Khan, Saeed, Zhang, Qin, Marasa, Bernard S, Sung, Kidon, Cerniglia, Carl E, Ingle, Taylor, Jones, Margie Yvonne, Paredes, Angel M, Tobin, Grainne A, Bancos, Simona, Weaver, James L, Goering, Peter L, Howard, Paul C, Patri, Anil K, Tyner, Katherine M
Format Journal Article
LanguageEnglish
Published England Future Medicine Ltd 01.09.2017
Subjects
Acids
Administration, Intravenous
Animals
Bacterial infections
bioaccumulation
biopersistence
Cancer
Cell Survival
Drug dosages
durable nanoparticles
Female
Gold - chemistry
host resistance
Humans
Infections
Listeria
Listeria monocytogenes - drug effects
Listeriosis - drug therapy
Listeriosis - metabolism
Listeriosis - microbiology
macrophage function
Macrophages - cytology
Macrophages - drug effects
Medical equipment
Mice
Mice, Inbred BALB C
Nanomaterials
Nanoparticles
Nanoparticles - chemistry
Particle Size
RAW 264.7 Cells
Reactive Oxygen Species - metabolism
Silicon Dioxide - chemistry
Silver
Silver - chemistry
Surface Properties
Tissue Distribution
United States > US
bioaccumulation
macrophage function
biopersistence
durable nanoparticles
host resistance
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Summary:The goal of this study was to determine whether bacterial clearance in a rodent model would be impaired upon exposure to gold, silver or silica nanoparticles (NPs). Mice received weekly injections of NPs followed by a challenge of (LM). On days 3 and 10 after LM injections, the animals were sacrificed and their tissues were collected for elemental analysis, electron microscopy and LM count determination. The untreated and NP-treated animals cleared LM at the same rate suggesting that bioaccumulation of NPs did not increase the animals' susceptibility to bacterial infection. The data from this study indicate that the bioaccumulation of NPs does not significantly affect the ability to react to a bacterial challenge.
ISSN:1743-5889
1748-6963
DOI:10.2217/nnm-2017-0176