The E-Box of the Human Glycophorin B Promoter Is Involved in the Erythroid-Specific Expression of the GPB Gene
Previous studies performed on the glycophorin B (GPB) expression demonstrated that this gene is expressed in erythroid cells only and that the ubiquitous factor Ku70 is involved in the process. Here, we investigated the contribution of the −70 E-box sequence toward the GPB promoter expression. We fo...
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| Published in | Biochemical and biophysical research communications Vol. 265; no. 1; pp. 170 - 176 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
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Elsevier Inc
11.11.1999
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| Abstract | Previous studies performed on the glycophorin B (GPB) expression demonstrated that this gene is expressed in erythroid cells only and that the ubiquitous factor Ku70 is involved in the process. Here, we investigated the contribution of the −70 E-box sequence toward the GPB promoter expression. We found that the E-box bound two factors, the USF1/USF2 protein and an unidentified ubiquitous protein which was named factor U. Site-directed mutagenesis performed on the −70 E-box showed that the USF factor had an activating effect in CAT assays. Conversely, mutation of the −70 E-box that impaired the binding of factor U led to a positive CAT activity in nonerythroid cells and thus to the loss of the erythroid-specific expression of the GPB gene. This indicates that, in addition to the Ku70 factor, the extinction of the GPB promoter expression in nonerythroid cells depends also on the repressing effect of the factor U. |
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| AbstractList | Previous studies performed on the glycophorin B (GPB) expression demonstrated that this gene is expressed in erythroid cells only and that the ubiquitous factor Ku70 is involved in the process. Here, we investigated the contribution of the −70 E-box sequence toward the GPB promoter expression. We found that the E-box bound two factors, the USF1/USF2 protein and an unidentified ubiquitous protein which was named factor U. Site-directed mutagenesis performed on the −70 E-box showed that the USF factor had an activating effect in CAT assays. Conversely, mutation of the −70 E-box that impaired the binding of factor U led to a positive CAT activity in nonerythroid cells and thus to the loss of the erythroid-specific expression of the GPB gene. This indicates that, in addition to the Ku70 factor, the extinction of the GPB promoter expression in nonerythroid cells depends also on the repressing effect of the factor U. Previous studies performed on the glycophorin B (GPB) expression demonstrated that this gene is expressed in erythroid cells only and that the ubiquitous factor Ku70 is involved in the process. Here, we investigated the contribution of the -70 E-box sequence toward the GPB promoter expression. We found that the E-box bound two factors, the USF1/USF2 protein and an unidentified ubiquitous protein which was named factor U. Site-directed mutagenesis performed on the -70 E-box showed that the USF factor had an activating effect in CAT assays. Conversely, mutation of the -70 E-box that impaired the binding of factor U led to a positive CAT activity in nonerythroid cells and thus to the loss of the erythroid-specific expression of the GPB gene. This indicates that, in addition to the Ku70 factor, the extinction of the GPB promoter expression in nonerythroid cells depends also on the repressing effect of the factor U. |
| Author | Camara-Clayette, Valérie Cartron, Jean-Pierre Rahuel, Cécile Bertrand, Olivier |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/10548509$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1182_blood_2008_06_164954 crossref_primary_10_1128_MCB_01186_10 crossref_primary_10_1128_MCB_24_4_1439_1452_2004 crossref_primary_10_1081_CBI_120022525 crossref_primary_10_1186_bcr2450 crossref_primary_10_1182_blood_2003_09_3107 crossref_primary_10_1074_jbc_M203909200 crossref_primary_10_1182_blood_2005_07_027037 crossref_primary_10_1074_jbc_M401356200 |
| Cites_doi | 10.1038/sj.onc.1202026 10.1016/0092-8674(85)90174-6 10.1182/blood.V80.3.575.575 10.1128/MCB.7.2.725 10.1128/MCB.19.2.1508 10.1016/0022-2836(89)90273-8 10.1093/nar/22.3.338 10.1002/stem.5530110204 10.1002/bies.950160707 10.1074/jbc.272.1.369 10.1002/j.1460-2075.1986.tb04537.x 10.1016/0003-2697(76)90527-3 10.1093/emboj/16.11.3145 10.1093/nar/11.5.1475 10.1093/nar/15.13.5490 10.1002/j.1460-2075.1992.tb05502.x 10.1016/0092-8674(85)90021-2 10.1016/S0021-9258(17)46702-0 10.1002/jss.400090109 10.1128/MCB.2.9.1044 10.1074/jbc.271.3.1405 10.1093/nar/27.7.1656 10.1093/nar/19.9.2499 |
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| Snippet | Previous studies performed on the glycophorin B (GPB) expression demonstrated that this gene is expressed in erythroid cells only and that the ubiquitous... |
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| SubjectTerms | Antigens, Nuclear Base Sequence blood group proteins Chloramphenicol O-Acetyltransferase - genetics DNA Helicases DNA-Binding Proteins - metabolism erythroid-specific expression Gene Expression Regulation Genes, Reporter Glycophorin - genetics HeLa Cells Humans K562 Cells Ku Autoantigen Mutagenesis, Site-Directed Nuclear Proteins - metabolism Oligodeoxyribonucleotides Point Mutation Promoter Regions, Genetic Recombinant Fusion Proteins - biosynthesis repressors transcription factors Transcription Factors - metabolism Transfection Upstream Stimulatory Factors |
| Title | The E-Box of the Human Glycophorin B Promoter Is Involved in the Erythroid-Specific Expression of the GPB Gene |
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