The regenerative therapies of the ankle degeneration: a focus on multipotential mesenchymal stromal cells

The ankle degeneration ranging from focal osteochondral lesions to osteoarthritis can cause a total joint function loss. With rising life expectancy and activity of the patients, various regenerative therapies were introduced aiming to preserve the joint function via the induction of cartilage and b...

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Published inRegenerative medicine Vol. 13; no. 2; pp. 175 - 188
Main Authors El-Jawhari, Jehan J, Brockett, Claire L, Ktistakis, Ioannis, Jones, Elena, Giannoudis, Peter V
Format Journal Article
LanguageEnglish
Published England Future Medicine Ltd 01.03.2018
Subjects
Ankle
Arthritis
bone
Bone marrow
cartilage
cell therapy
Cytokines
Fractures
Ligaments
mesenchymal (multipotential) stromal cells
osteoarthritis
osteochondral lesion
Pain
regeneration
Stem cells
Trauma
regeneration
cell therapy
mesenchymal (multipotential) stromal cells
osteoarthritis
cartilage
bone
osteochondral lesion
ankle
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Summary:The ankle degeneration ranging from focal osteochondral lesions to osteoarthritis can cause a total joint function loss. With rising life expectancy and activity of the patients, various regenerative therapies were introduced aiming to preserve the joint function via the induction of cartilage and bone repair. Here, biological events and mechanical changes of the ankle degeneration were discussed. The regenerative therapies were reviewed versus the standard surgical treatment. We especially focused on the use of mesenchymal (multipotential) stromal cells (MSCs) highlighting their dual functions of regeneration and cell modulation with an emphasis on the emerging MSC-based clinical studies. Being at an early step, more basic and clinical research is needed to optimize the applications of all ankle regenerative therapies including MSC-based methods.
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ISSN:1746-0751
1746-076X
DOI:10.2217/rme-2017-0104