Application and mechanism of manganese-coated caramelization nanospheres for active targeting in hepatobiliary tumors

• Published in: Nanomedicine (London, England) Vol. 14; no. 22; pp. 2973 - 2985
• Main Authors: Qi, Yafei, Li, Wenqin, Fang, Jiayang, Xiang, Ying, Zhu, Mingquan, Zhang, Xiaoming, Ma, Xiangxing, Wang, Qing, Zhan, Jinhua, Yu, Dexin
• Format: Journal Article
• Language: English
• Published: England Future Medicine Ltd 01.11.2019
• Subjects: active targeting; Animal research; caramelization nanospheres; Contrast agents; Cytotoxicity; Experiments; Flow cytometry; Fourier transforms; Glucose; hepatobiliary cancer; Laboratory animals; Ligands; Liver cancer; manganese oxide; Medical research; MRI; Tumors; United States > US; China; manganese oxide; hepatobiliary cancer; caramelization nanospheres; MRI; active targeting
• ISSN: 1743-5889; 1748-6963; 1748-6963
• DOI: 10.2217/nnm-2018-0272

To elucidate the MRI mechanisms of manganese oxide-coated carbohydration nanosphere (Mn@CNS) for active targeting in hepatobiliary tumors. The cytotoxicity, internalization pathway, metabolism and excretion pathway of Mn@CNS were assessed by several cell types. The MRI of Mn@CNS was verified via rat models bearing hepatobiliary tumors. Mn@CNS showed no obvious cytotoxicity. Mice macrophage and hepatocellular Mn content significantly differed between pre- and post-uptake levels (p < 0.01). The animal experiment revealed fine T1 imaging of hepatobiliary tumors with peak enhancement at 3 h. Mn@CNS was metabolized within the cells and excreted mainly via feces. Mn@CNS is safe, biodegradable, and may serve as a new strategy for active target imaging and treatment applications.