Lower circulating migration inhibitory factor protein is associated with metabolic syndrome and diabetes

• Published in: Biomarkers in medicine Vol. 11; no. 7; pp. 557 - 568
• Main Authors: Onat, Altan, Ademo lu, Evin, Can, Günay, Çoban, Neslihan, Kaya, Ay em, Yüksel, Hüsniye
• Format: Journal Article
• Language: English
• Published: England Future Medicine Ltd 01.07.2017
• Subjects: Adult; Adults; Aged; Aged, 80 and over; Angina pectoris; Apolipoproteins; Cardiovascular disease; Cholesterol; Coronary artery disease; Coronary Artery Disease - blood; Coronary Artery Disease - genetics; coronary heart disease; Diabetes mellitus; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - genetics; Electrocardiography; Fasting; Female; Gender; Gene-Environment Interaction; Gestational diabetes; Glucose; Heart diseases; Humans; inflammation; Insulin resistance; Intramolecular Oxidoreductases - blood; Leukocyte migration; Macrophage migration inhibitory factor; Macrophage Migration-Inhibitory Factors - blood; Male; Males; Metabolic syndrome; Metabolic Syndrome - blood; Metabolic Syndrome - genetics; Metabolism; Middle Aged; Migration inhibitory factor; Obesity; Population; Proteins; Risk Factors; serum MIF protein; Sexes; Testosterone; Triglycerides; Type 2 diabetes; Weight control; Womens health; United States > US; Germany; Type 2 diabetes; metabolic syndrome; serum MIF protein; coronary heart disease; inflammation
• ISSN: 1752-0363; 1752-0371; 1752-0371
• DOI: 10.2217/bmm-2016-0359

The controversial relationship between macrophage migration inhibitory factor (MIF) and the likelihood of cardiometabolic diseases was investigated. Assayed MIF protein from 1225 adults was cross-sectionally analyzed. MIF was independently inversely associated with age, total testosterone and positively with high-density lipoprotein-cholesterol. In men MIF correlation with age, testosterone and waist circumference converted from inverse in the upper to positive in the bottom MIF third. Both metabolic syndrome and diabetes were significantly associated, in combined gender, with the intermediate (vs the highest) MIF tertile at an odds ratio 1.6. Coronary heart disease was not significantly related with MIF in either gender. Findings are consistent with oxidative damage to MIF protein and its involvement in autoimmune activation, likely more extensive in women.