Isozyme pattern of thymidine kinase during liver regeneration

Liver regeneration after partial hepatectomy is characterized by an active phase of cell proliferation that is associated with a marked increase in thymidine kinase activity. Using non-denaturing gel electrophoresis and different substrate specificity, two isozymes could be detected. One was identif...

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Bibliographic Details
Published inHoppe-Seyler's Zeitschrift für Physiologische Chemie Vol. 365; no. 4; p. 457
Main Authors Coloma, J, Castell, J V
Format Journal Article
LanguageEnglish
Published Germany 01.01.1984
Subjects
Animals
Cytidine Triphosphate - metabolism
Electrophoresis, Polyacrylamide Gel
Female
Fetus - metabolism
Isoenzymes - analysis
Liver - embryology
Liver - enzymology
Liver Regeneration
Male
Pregnancy
Rats
Rats, Inbred Strains
Thymidine Kinase - analysis
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Summary:Liver regeneration after partial hepatectomy is characterized by an active phase of cell proliferation that is associated with a marked increase in thymidine kinase activity. Using non-denaturing gel electrophoresis and different substrate specificity, two isozymes could be detected. One was identified as the adult isozyme while the other was the fetal one. Both forms were present during liver regeneration. When the regenerative process was completed, the total enzymatic activity dropped to normal values and the fetal isozyme was displaced by the adult type.
ISSN:0018-4888
DOI:10.1515/bchm2.1984.365.1.457